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Drilldown: Medicines

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Medicines > fda max : 400 mg/d (rarely used) or Indication-specific & onset: Urinary concentration adequate within hours

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generic:
Nitrofurantoin (1)
brand:
Macrobid (monohydrate/macrocrystals), Macrodantin (macrocrystals), Furadantin (suspension) (1)
classes:
[[:Category:Antibacterials|Antibacterial]] (1) · [[:Category:Nitrofurans|Nitrofuran]] (1) · [[:Category:Urinary_anti-infectives|Urinary anti-infective]] (1)
mechanism:
None (1)
uses:
'"`UNIQ--vote-000008A1-QINU`"', '"`UNIQ--vote-000008A2-QINU`"' (1)
starting dose:
100 mg PO BID × 5 days (Macrobid) for cystitis; 50-100 mg HS for chronic prophylaxis (1)
preparations:
25 mg/5 mL suspension; 25, 50, 100 mg capsules (Macrodantin); 100 mg Macrobid capsule (1)
fda max: (Click arrow to add another value)
routes:
Oral (1)
onset: (Click arrow to add another value)
duration:
12 hours (Macrobid) (1)
halflife:
~20-60 minutes (plasma; not the relevant kinetic since urinary concentration matters)'"`UNIQ--ref-000008A3-QINU`"' (1)
bioavailability:
~90% (oral; food increases absorption)'"`UNIQ--ref-000008A4-QINU`"' (1)
pregnancy:
'''Avoid at term (38-42 weeks) and during labor''' (risk of neonatal hemolytic anemia, especially with G6PD deficiency); generally safe in earlier pregnancy.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
[[USLegal:Prescription only|Rx-only]] in US (1)

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