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Medicines > fda max : 450 mg/day; doses above this raise seizure risk steeply or TID per eye & routes: topical skin

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generic:
Brimonidine (1)
brand:
Alphagan P (ophthalmic glaucoma), Mirvaso (topical rosacea) (1)
classes:
[[:Category:Alpha-2_agonists|Alpha-2 adrenergic agonist]] (1) · [[:Category:Glaucoma_medications|Glaucoma medication]] (1) · [[:Category:Ocular_hypotensive_agents|Ocular hypotensive agent]] (1)
mechanism:
None (1)
uses:
'"`UNIQ--vote-000010CE-QINU`"', '"`UNIQ--vote-000010CF-QINU`"', '"`UNIQ--vote-000010D0-QINU`"' (1)
starting dose:
Ophthalmic 1 drop in affected eye(s) TID; topical Mirvaso 0.33% gel applied to face daily (1)
preparations:
0.1%, 0.15%, 0.2% ophthalmic solutions; 0.33% topical gel; combinations with timolol (Combigan) and brinzolamide (Simbrinza) (1)
fda max: (Click arrow to add another value)
routes: (Click arrow to add another value)
onset:
IOP lowering at 1 hour; max at 2-3 hours (1)
duration:
8-12 hours (1)
halflife:
~3 hours'"`UNIQ--ref-000010D1-QINU`"' (1)
bioavailability:
Topical; clinically meaningful systemic absorption can produce systemic α2 effects (somnolence, hypotension), especially in children'"`UNIQ--ref-000010D2-QINU`"' (1)
pregnancy:
Limited data.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
[[USLegal:Prescription only|Rx-only]] in US (1)

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