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Medicines > fda max : 600 mg/d or No strict ceiling for water-soluble vitamin; UL not set & routes: oral

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generic:
Cefdinir (1) · Riboflavin (vitamin B2) (1)
brand:
Many generics/OTC (1) · Omnicef (discontinued in US under brand); mostly generic (1)
classes:
[[:Category:B-vitamins|B-vitamin]] (1) · [[:Category:Beta-lactam_antibiotics|β-lactam antibiotic]] (1) · [[:Category:Cephalosporins|Cephalosporin (third-generation)]] (1) · [[:Category:Vitamins|Vitamin]] (1)
mechanism:
None (1) · '"`UNIQ--vote-0000124C-QINU`"' The 400 mg/d dose for migraine prophylaxis is supported by randomized trials (Schoenen 1998) and remains a low-risk evidence-based supplement option. Characteristic bright-yellow urine fluorescence with high-dose oral supplementation. (1)
uses:
'"`UNIQ--vote-000009DF-QINU`"', '"`UNIQ--vote-000009E0-QINU`"', '"`UNIQ--vote-000009E1-QINU`"', '"`UNIQ--vote-000009E2-QINU`"', '"`UNIQ--vote-000009E3-QINU`"' (1) · '"`UNIQ--vote-0000124D-QINU`"', '"`UNIQ--vote-0000124E-QINU`"', '"`UNIQ--vote-0000124F-QINU`"' (1)
starting dose:
300 mg PO BID, or 600 mg PO once daily, ×5-10 days; pediatric 14 mg/kg/d (1) · Migraine prophylaxis: 400 mg PO daily; deficiency replacement 5-30 mg/d (1)
preparations:
25, 50, 100, 250, 400 mg tablets; OTC (1) · 300 mg capsules; 125, 250 mg/5 mL suspension (1)
fda max: (Click arrow to add another value)
routes: (Click arrow to add another value)
onset:
Hours (1) · Migraine effect after 1-3 months of daily use (1)
duration:
12-24 hours (1) · N/A (1)
halflife:
~1-2 hours plasma (riboflavin itself); FAD/FMN tissue cofactors are continuous (1) · ~1.7 hours'"`UNIQ--ref-000009E4-QINU`"' (1)
bioavailability:
16-21% capsule, 25% suspension (oral; iron and antacids reduce absorption substantially)'"`UNIQ--ref-000009E5-QINU`"' (1) · ~50-60% (oral; food enhances) (1)
pregnancy:
Generally considered safe in pregnancy.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1) · Safe at replacement and supplement doses.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
OTC in US (1) · [[USLegal:Prescription only|Rx-only]] in US (1)

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