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Medicines > fda max : 600 mg/d or UL 1000 mg (~1500 IU natural)/d in adults; routinely exceeded in older AREDS-1 trials & routes: Oral

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generic:
Cefdinir (1) · Vitamin E (α-tocopherol; mixed natural and synthetic forms) (1)
brand:
Generic; many OTC formulations (1) · Omnicef (discontinued in US under brand); mostly generic (1)
classes:
[[:Category:Antioxidants|Antioxidant]] (1) · [[:Category:Beta-lactam_antibiotics|β-lactam antibiotic]] (1) · [[:Category:Cephalosporins|Cephalosporin (third-generation)]] (1) · [[:Category:Fat-soluble_vitamins|Fat-soluble vitamin]] (1) · [[:Category:Vitamins|Vitamin]] (1)
mechanism:
None (2)
uses:
'"`UNIQ--vote-000009DF-QINU`"', '"`UNIQ--vote-000009E0-QINU`"', '"`UNIQ--vote-000009E1-QINU`"', '"`UNIQ--vote-000009E2-QINU`"', '"`UNIQ--vote-000009E3-QINU`"' (1) · '"`UNIQ--vote-000012CE-QINU`"', '"`UNIQ--vote-000012CF-QINU`"', '"`UNIQ--vote-000012D0-QINU`"' (1)
starting dose:
300 mg PO BID, or 600 mg PO once daily, ×5-10 days; pediatric 14 mg/kg/d (1) · Replacement: 15-30 mg (22.5-45 IU) daily; NASH: 800 IU daily; AREDS-2: 400 IU daily (in combination formula) (1)
preparations:
100, 200, 400 IU softgels and capsules; many proprietary OTC blends; combined formulations (AREDS-2) (1) · 300 mg capsules; 125, 250 mg/5 mL suspension (1)
fda max: (Click arrow to add another value)
routes: (Click arrow to add another value)
onset:
Days to weeks for tissue saturation (1) · Hours (1)
duration:
12-24 hours (1) · Weeks (fat-soluble) (1)
halflife:
~1.7 hours'"`UNIQ--ref-000009E4-QINU`"' (1) · ~3-4 days plasma; adipose tissue stores last months (1)
bioavailability:
16-21% capsule, 25% suspension (oral; iron and antacids reduce absorption substantially)'"`UNIQ--ref-000009E5-QINU`"' (1) · High with fat-containing meal; reduced in malabsorption (1)
pregnancy:
Generally considered safe in pregnancy.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1) · Safe at replacement doses; high-dose use generally avoided.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
OTC in US (1) · [[USLegal:Prescription only|Rx-only]] in US (1)

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