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Medicines > generic: Allopurinol & fda max : 800 mg/d (rarely needed) or No fixed maximum; titrated to TSH target

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generic: (Click arrow to add another value)
brand:
Zyloprim, Aloprim (IV) (1)
classes:
[[:Category:Antigout_agents|Antigout agent]] (1) · [[:Category:Antihyperuricemic_agents|Antihyperuricemic agent]] (1) · [[:Category:Xanthine_oxidase_inhibitors|Xanthine oxidase inhibitor]] (1)
mechanism:
None (1)
uses:
'"`UNIQ--vote-0000030B-QINU`"', '"`UNIQ--vote-0000030C-QINU`"', '"`UNIQ--vote-0000030D-QINU`"', '"`UNIQ--vote-0000030E-QINU`"' (1)
starting dose:
100 mg PO once daily; titrate by 100 mg every 2-4 weeks to a serum urate target (typically <6 mg/dL, or <5 in tophaceous disease) (1)
preparations:
100 mg, 300 mg tablets; IV 500 mg vial (1)
fda max: (Click arrow to add another value)
routes:
IV (1) · Oral (1)
onset:
Serum urate falls gradually over days to weeks; acute flare prevention requires colchicine cover during initiation (1)
duration:
24 hours (1)
halflife:
1-2 hours (parent); 18-30 hours for active metabolite oxypurinol'"`UNIQ--ref-0000030F-QINU`"' (1)
bioavailability:
~80% (oral)'"`UNIQ--ref-00000310-QINU`"' (1)
pregnancy:
Limited safety data; weigh benefit individually.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
[[USLegal:Prescription only|Rx-only]] in US (1)

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