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Drilldown: Medicines

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Medicines > fda max : Formulation-specific; ~4.8 g/d typical maximum oral or None & routes: transdermal

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generic:
Methylphenidate (1)
brand:
Ritalin, Ritalin LA, Concerta, Metadate CD, Daytrana, Quillivant XR (1)
classes:
NDRI (1) · Psychostimulant (1)
mechanism:
Norepinephrine–dopamine reuptake inhibition (DAT, NET) (1)
uses:
ADHD, narcolepsy (1)
starting dose:
None (1)
preparations:
None (1)
fda max: (Click arrow to add another value)
routes: (Click arrow to add another value)
onset:
20–60 min (oral) (1)
duration:
IR 3–5 h; LA/SR 6–8 h; Concerta 10–12 h; Daytrana ~9 h wear time (1)
halflife:
2–3 h (parent compound) (1)
bioavailability:
~30% (high first-pass) (1)
pregnancy:
Pregnancy categories were retired by FDA in 2015. Limited reproductive data with small observational signal for cardiac malformations; risk-benefit decision, with many patients deferring ADHD treatment during pregnancy. See pregnancy_details for the full discussion. (1)
legal:
Schedule II (1)

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