Jump to content

Drilldown: Medicines

Nav

Choose a table:

Medicines (732)

Medicines > generic: None

& fda max

: 10 mg/d

or 195 units/treatment for chronic migraine; max varies by problem

Use the filters below to narrow your results.

Botox (1) · Dayvigo (1)

Dual orexin receptor antagonist (DORA) (1) · neuromuscular blocker (presynaptic) (1) · Neurotoxin (1)

Cleaves SNAP-25 protein in presynaptic motor and autonomic nerve terminals, blocking acetylcholine release; in chronic migraine, hypothesized to inhibit peripheral sensitization of trigeminovascular nociceptors (1) · Competitive antagonist at OX1R and OX2R. Faster receptor association/dissociation kinetics than suvorexant (~16 sec dissociation vs ~57 sec) hypothesized to support sleep onset, with sufficient duration for maintenance. (1)

Chronic migraine (≥15 headache days/month), cervical dystonia, blepharospasm, hyperhidrosis, overactive bladder, urinary incontinence, strabismus, spasticity, cosmetic problems (1) · Insomnia (sleep onset and/or maintenance) in adults (FDA-approved Dec 2019) (1)

5 mg PO at bedtime; may increase to 10 mg if inadequate (1) · Chronic migraine (PREEMPT protocol): 155 units divided across 31 sites in 7 head/neck muscle groups every 12 weeks (1)

5 mg, 10 mg tablets (1) · 50, 100, or 200 unit vials of lyophilized powder for reconstitution (1)

Intramuscular (PREEMPT injections for migraine) (1) · Oral (1)

1–2 weeks for muscle effects; preventive migraine benefit accrues over 12-week cycles (1) · ~30 min (1)

~12 weeks (1) · ~7-8 hours (1)

Tissue half-life not formally measured; clinical effect ~12 weeks (1) · ~17-19 hours (longer than daridorexant) (1)

Local (intramuscular) (1) · ~44% (1)

Category C; limited data (1) · Limited data; avoid (1)

Rx, Schedule IV (US) (1) · Rx; black-box warning for distant spread of toxin effect (1)

Showing below up to 2 results in range #1 to #2.

L

Lemborexant

O

Onabotulinumtoxin A

Retrieved from "https://pharmacopedia.wiki/p/Special:Drilldown/Medicines"