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Drilldown: Medicines

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Medicines > fda max : One dose per day or Titrated to glucose; no fixed ceiling & routes: Inhaled (DPI

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generic:
Tiotropium (1)
brand:
Spiriva, Spiriva Respimat (1)
classes:
[[:Category:Antimuscarinics|Antimuscarinic]] (1) · [[:Category:Bronchodilators|Bronchodilator]] (1) · [[:Category:Long-acting_muscarinic_antagonists|Long-acting muscarinic antagonist (LAMA)]] (1)
mechanism:
None (1)
uses:
'"`UNIQ--vote-000009BE-QINU`"', '"`UNIQ--vote-000009BF-QINU`"' (1)
starting dose:
18 mcg DPI once daily (HandiHaler); 2.5 mcg per actuation × 2 inhalations once daily (Respimat) (1)
preparations:
18 mcg HandiHaler capsules; 2.5 mcg/actuation Respimat solution inhaler (1.25 mcg/actuation for asthma indication) (1)
fda max: (Click arrow to add another value)
routes: (Click arrow to add another value)
onset:
Bronchodilation 30 minutes; steady-state at 1-2 weeks (1)
duration:
24 hours (long receptor dissociation half-life from M3) (1)
halflife:
~25-44 hours plasma; receptor kinetics drive the once-daily duration'"`UNIQ--ref-000009C0-QINU`"' (1)
bioavailability:
Inhaled lung deposition ~20%; systemic absorption from lung ~33%; oral component negligible'"`UNIQ--ref-000009C1-QINU`"' (1)
pregnancy:
Limited data; LABA/LAMA strategies in pregnancy generally favor agents with the most reassuring data.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
[[USLegal:Prescription only|Rx-only]] in US (1)

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