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Medicines > generic : Alprazolam or None & fda max: 10 mg/d

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generic: (Click arrow to add another value)
brand:
Dayvigo (1) · Xanax (1)
classes:
Anxiolytic (1) · Benzodiazepine (1) · Dual orexin receptor antagonist (DORA) (1) · Triazolobenzodiazepine (1)
mechanism:
Competitive antagonist at OX1R and OX2R. Faster receptor association/dissociation kinetics than suvorexant (~16 sec dissociation vs ~57 sec) hypothesized to support sleep onset, with sufficient duration for maintenance. (1) · GABA-A positive allosteric modulator'"`UNIQ--ref-00000067-QINU`"' '"`UNIQ--vote-00000068-QINU`"' (1)
uses:
Insomnia (sleep onset and/or maintenance) in adults (FDA-approved Dec 2019) (1) · '"`UNIQ--vote-00000069-QINU`"', '"`UNIQ--vote-0000006A-QINU`"', '"`UNIQ--vote-0000006B-QINU`"' (1)
starting dose:
0.25 mg (1) · 5 mg PO at bedtime; may increase to 10 mg if inadequate (1)
preparations:
0.25 mg, 0.5 mg, 1 mg, 2 mg tablets (immediate-release and orally disintegrating); 0.5 mg, 1 mg, 2 mg, 3 mg extended-release tablets; 1 mg/mL oral concentrate (1) · 5 mg, 10 mg tablets (1)
fda max: (Click arrow to add another value)
routes:
Oral (2)
onset:
30-60 min (immediate-release); 1-2 h (extended-release) (1) · ~30 min (1)
duration:
6 h (immediate-release); ~11 h (extended-release) (1) · ~7-8 hours (1)
halflife:
11-13 h (immediate-release); 11-16 h (extended-release) (1) · ~17-19 hours (longer than daridorexant) (1)
bioavailability:
80-90% oral (1) · ~44% (1)
pregnancy:
Category D'"`UNIQ--ref-0000006C-QINU`"' (1) · Limited data; avoid (1)
legal:
Rx, Schedule IV (US) (1) · Schedule IV (US) (1)

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