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Medicines > fda max: 100 mg/d (rarely used) & routes : buccal); refined cocaine has its own profile or oral

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generic:
Chlorthalidone (1)
brand:
Thalitone; mostly prescribed generically (1)
classes:
[[:Category:Antihypertensives|Antihypertensive]] (1) · [[:Category:Thiazide-like_diuretics|Thiazide-like diuretic]] (1)
mechanism:
None (1)
uses:
'"`UNIQ--vote-00000780-QINU`"', '"`UNIQ--vote-00000781-QINU`"', '"`UNIQ--vote-00000782-QINU`"' (1)
starting dose:
12.5-25 mg PO once daily; titrate to 50 mg (1)
preparations:
15 mg, 25 mg, 50 mg tablets (1)
fda max: (Click arrow to add another value)
routes: (Click arrow to add another value)
onset:
Diuresis at 2-3 hours; BP effect over weeks (1)
duration:
48-72 hours per dose (much longer than hydrochlorothiazide) (1)
halflife:
40-60 hours (notable for the thiazide class)'"`UNIQ--ref-00000783-QINU`"' (1)
bioavailability:
~65% (oral)'"`UNIQ--ref-00000784-QINU`"' (1)
pregnancy:
Avoided where possible; same class concerns as HCTZ.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
[[USLegal:Prescription only|Rx-only]] in US (1)

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