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Drilldown: Medicines

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Medicines > generic: Etodolac & fda max: 1000 mg/d (osteoarthritis); 1200 mg/d (rheumatoid arthritis)

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generic: (Click arrow to add another value)
brand:
Lodine (US brand discontinued); generic (1)
classes:
[[:Category:NSAIDs|Non-steroidal anti-inflammatory drug (NSAID)]] (1) · [[:Category:Pyranocarboxylic_acid_derivatives|Pyranocarboxylic acid derivative]] (1)
mechanism:
'"`UNIQ--vote-00001269-QINU`"' Renal, GI, hypertensive, and CV effects parallel the class profile; modest COX-2 preference may underlie some literature suggesting slightly better GI tolerability than non-selective NSAIDs, though clinically the difference is small'"`UNIQ--ref-0000126A-QINU`"'. (1)
uses:
'"`UNIQ--vote-0000126B-QINU`"', '"`UNIQ--vote-0000126C-QINU`"', '"`UNIQ--vote-0000126D-QINU`"' (1)
starting dose:
IR 200-400 mg PO every 6-8 hours; ER 400-1000 mg PO once daily (1)
preparations:
200, 300, 400, 500 mg IR tablets/capsules; 400, 500, 600 mg ER tablets (1)
fda max: (Click arrow to add another value)
routes:
Oral (1)
onset:
Analgesia within 30 minutes; full anti-inflammatory effect over days (1)
duration:
6-8 hours (IR); 24 hours (ER) (1)
halflife:
~7 hours'"`UNIQ--ref-0000126E-QINU`"' (1)
bioavailability:
~100% (oral; absorption complete)'"`UNIQ--ref-0000126F-QINU`"' (1)
pregnancy:
Avoid after 20 weeks (NSAID-class FDA 2020 advisory).<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
[[USLegal:Prescription only|Rx-only]] in US. NSAID-class '''Boxed Warning''' for CV thrombotic events and GI bleeding'"`UNIQ--ref-00001270-QINU`"' (1)

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