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Medicines (732)

Medicines > generic

: Vardenafil

or None

& fda max: 20 mg/d

Use the filters below to narrow your results.

Belsomra (1) · Levitra, Staxyn (1) · Trintellix (US), Brintellix (formerly) (1)

Dual orexin receptor antagonist (DORA) (1) · Multimodal antidepressant: SERT inhibitor + 5HT1A agonist + 5HT1B partial agonist + 5HT3/5HT7 antagonist (1) · PDE5 Inhibitor (1) · the first approved (1)

None (1) · Competitive antagonist at OX1R and OX2R. First-in-class DORA. Receptor dissociation slower than lemborexant or daridorexant. (1) · Selective inhibitor of PDE5. Slightly higher PDE5/PDE6 selectivity vs sildenafil (less visual side effect) but more PDE1 cross-activity (occasional QT effects at high doses). (1)

Insomnia (sleep onset and/or maintenance) in adults (FDA-approved August 2014). Also studied for insomnia in mild-moderate Alzheimer disease. (1) · Major depressive disorder in adults (FDA-approved 2013). Notable for evidence of cognitive benefit (processing speed) that distinguishes it from other antidepressants. (1) · '"`UNIQ--vote-00000669-QINU`"' (1)

10 mg PO 30 min before bedtime (with ≥7 hours of sleep planned) (1) · 10 mg PO once daily; may increase to 20 mg as tolerated, or decrease to 5 mg if needed (1) · 10 mg ~1 h before sexual activity (1)

2.5, 5, 10, 20 mg tabs (Levitra); 10 mg ODT (Staxyn) (1) · 5 mg, 10 mg, 15 mg, 20 mg tablets (1) · 5 mg, 10 mg, 20 mg tablets (1)

Oral (3)

Typical antidepressant 4-6 week onset (1) · ~30 min (2)

4–5 h (1) · Daily dosing (1) · ~7-8 hours (1)

4–5 h (1) · ~12 hours (1) · ~66 hours (1)

~15% (extensive hepatic first-pass) (1) · ~75% (1) · ~82% (1)

Category B (1) · Limited data; avoid (1) · Limited data; weigh benefits/risks (1)

Rx (1) · Rx, Schedule IV (US) (1) · Rx-only in US (1)

Showing below up to 3 results in range #1 to #3.

S

Suvorexant

V

Vardenafil

Vortioxetine

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