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Medicines > fda max: 20 mg/day (adult); 10 mg/day in elderly and in hepatic impairment & routes: Oral

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generic:
Escitalopram (1)
brand:
Lexapro (1)
classes:
[[:Category:Antidepressants|Antidepressant]] (1) · [[:Category:Anxiolytics|Anxiolytic]] (1) · [[:Category:SSRIs|Selective serotonin reuptake inhibitor (SSRI)]] (1)
mechanism:
'"`UNIQ--vote-0000001D-QINU`"' CYP2C19 + CYP3A4 metabolism, with CPIC PGx guidance: poor CYP2C19 metabolizers have ~3-fold higher exposure and benefit from a lower starting dose; ultrarapid metabolizers may have inadequate response'"`UNIQ--ref-0000001E-QINU`"'. (1)
uses:
'"`UNIQ--vote-0000001F-QINU`"', '"`UNIQ--vote-00000020-QINU`"', '"`UNIQ--vote-00000021-QINU`"', '"`UNIQ--vote-00000022-QINU`"', '"`UNIQ--vote-00000023-QINU`"', '"`UNIQ--vote-00000024-QINU`"', '"`UNIQ--vote-00000025-QINU`"' (1)
starting dose:
10 mg PO once daily; titrate to 20 mg/day after 1-2 weeks if needed (1)
preparations:
Tablets 5, 10, 20 mg; oral solution 1 mg/mL (1)
fda max: (Click arrow to add another value)
routes: (Click arrow to add another value)
onset:
Antidepressant effect emerges over 1-2 weeks; full clinical effect 4-6 weeks (1)
duration:
24 hours (once-daily dosing) (1)
halflife:
27-32 hours'"`UNIQ--ref-00000026-QINU`"' (1)
bioavailability:
~80% (oral)'"`UNIQ--ref-00000027-QINU`"' (1)
pregnancy:
None (1)
legal:
[[USLegal:Prescription only|Rx-only]] in US. Carries the antidepressant '''Boxed Warning''' for suicidality in children, adolescents, and young adults'"`UNIQ--ref-00000028-QINU`"' (1)

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