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Medicines > fda max: 200 mg/d typical practical ceiling & routes : IV (prednisolone sodium phosphate) or Oral

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generic:
Torsemide (1)
brand:
Demadex, Soaanz (1)
classes:
[[:Category:Loop_diuretics|Loop diuretic]] (1)
mechanism:
'"`UNIQ--vote-00000B40-QINU`"' The TRANSFORM-HF trial (2023) found no all-cause mortality difference between torsemide and furosemide in heart failure, although torsemide remains pharmacologically preferred where furosemide oral absorption is unreliable'"`UNIQ--ref-00000B41-QINU`"'. (1)
uses:
'"`UNIQ--vote-00000B42-QINU`"', '"`UNIQ--vote-00000B43-QINU`"', '"`UNIQ--vote-00000B44-QINU`"', '"`UNIQ--vote-00000B45-QINU`"' (1)
starting dose:
10-20 mg PO/IV once daily; titrate by clinical response. 1:1 IV to PO conversion (unlike furosemide's 1:2) (1)
preparations:
5, 10, 20, 100 mg tablets; 10 mg/mL IV (1)
fda max: (Click arrow to add another value)
routes: (Click arrow to add another value)
onset:
PO 1 hour; IV 10 minutes (1)
duration:
6-8 hours (1)
halflife:
3-4 hours (similar between PO and IV due to high oral bioavailability)'"`UNIQ--ref-00000B46-QINU`"' (1)
bioavailability:
~80% (oral; predictable absorption — a substantive practical advantage over furosemide whose oral absorption is 10-100% variable)'"`UNIQ--ref-00000B47-QINU`"' (1)
pregnancy:
Avoid where possible; class concerns as for other loop diuretics.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
[[USLegal:Prescription only|Rx-only]] in US (1)

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