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Medicines > fda max: 2400 mg/day (oral); 300 mg total per IV bolus dosing series & routes : Oral or intravenous

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generic:
Labetalol (1)
brand:
Trandate, Normodyne (discontinued in US) (1)
classes:
[[:Category:Antihypertensives|Antihypertensive]] (1) · [[:Category:Beta blockers|Combined alpha-1 and non-selective beta blocker]] (1)
mechanism:
'"`UNIQ--vote-00000015-QINU`"' The favorable pregnancy safety profile and the dual mechanism support its first-line role in pregnancy-associated hypertension and in hypertensive emergencies where rapid, controllable BP reduction is needed'"`UNIQ--ref-00000016-QINU`"'. (1)
uses:
'"`UNIQ--vote-00000017-QINU`"', '"`UNIQ--vote-00000018-QINU`"', '"`UNIQ--vote-00000019-QINU`"' (1)
starting dose:
Oral: 100 mg PO BID, titrate to 400 mg BID. IV: 20 mg over 2 minutes, repeat 40-80 mg every 10 minutes as needed (maximum cumulative 300 mg); continuous infusion 2 mg/minute (1)
preparations:
Tablets 100, 200, 300 mg; injection 5 mg/mL (1)
fda max: (Click arrow to add another value)
routes: (Click arrow to add another value)
onset:
BP effect within hours (oral); 5-10 minutes (IV) (1)
duration:
8-12 hours (oral); 4-6 hours (IV) (1)
halflife:
~6-8 hours'"`UNIQ--ref-0000001A-QINU`"' (1)
bioavailability:
~25% (oral; extensive first-pass)'"`UNIQ--ref-0000001B-QINU`"' (1)
pregnancy:
'''Among the safest antihypertensives in pregnancy''', recommended for chronic hypertension during pregnancy and first-line for severe hypertension in preeclampsia and eclampsia'"`UNIQ--ref-0000001C-QINU`"' (1)
legal:
[[USLegal:Prescription only|Rx-only]] in US (1)

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