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Medicines > fda max: 4 g/d in healthy adults; 3 g/d conservative limit; 2 g/d in cirrhosis or chronic alcohol use & routes : rectal or vaginal

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generic:
Acetaminophen (paracetamol, APAP) (1)
brand:
Tylenol, Panadol (international), Ofirmev (IV); huge OTC presence (1)
classes:
[[:Category:Analgesics|Non-opioid analgesic]] (1) · [[:Category:Antipyretics|Antipyretic]] (1)
mechanism:
None (1)
uses:
'"`UNIQ--vote-000006A2-QINU`"', '"`UNIQ--vote-000006A3-QINU`"', '"`UNIQ--vote-000006A4-QINU`"' (1)
starting dose:
325-1000 mg PO every 4-6 hours as needed; maximum 4 g/d in healthy adults, 3 g/d in regular users or hepatic risk; pediatric 10-15 mg/kg every 4-6 hours (1)
preparations:
325, 500, 650 mg tablets; 80, 160 mg chewables; 160 mg/5 mL pediatric liquid; 325 mg suppository; 1000 mg/100 mL IV (Ofirmev); fixed-dose combinations with opioids, decongestants, antihistamines (1)
fda max: (Click arrow to add another value)
routes: (Click arrow to add another value)
onset:
PO: 30-60 minutes; IV: minutes (1)
duration:
4-6 hours (1)
halflife:
1-3 hours (normal liver); markedly prolonged in overdose with glutathione depletion'"`UNIQ--ref-000006A5-QINU`"' (1)
bioavailability:
~85-98% (oral)'"`UNIQ--ref-000006A6-QINU`"' (1)
pregnancy:
Long the preferred analgesic-antipyretic in pregnancy; recent observational studies have raised speculative neurodevelopmental signals that remain under investigation.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
OTC and [[USLegal:Prescription only|Rx-only]] (IV, combination products) in US (1)

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