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Medicines > generic : Codeine or Glipizide & fda max: 40 mg/d (IR; doses >15 mg given as divided BID); 20 mg/d (XL)

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generic: (Click arrow to add another value)
brand:
Glucotrol, Glucotrol XL (1)
classes:
[[:Category:Antihyperglycemic_agents|Antihyperglycemic agent]] (1) · [[:Category:Insulin_secretagogues|Insulin secretagogue]] (1) · [[:Category:Sulfonylureas|Sulfonylurea (second-generation)]] (1)
mechanism:
'"`UNIQ--vote-000002D7-QINU`"' Hypoglycemia is the central risk, especially in elderly and renally impaired patients (glipizide has shorter half-life than glyburide, which is one reason it is preferred in older adults). CYP2C9 substrate; weight gain typical. (1)
uses:
'"`UNIQ--vote-000002D8-QINU`"' (1)
starting dose:
5 mg PO once daily, 30 minutes before breakfast; XL: 5 mg with breakfast (1)
preparations:
5 mg, 10 mg immediate-release tablets; 2.5 mg, 5 mg, 10 mg extended-release tablets (1)
fda max: (Click arrow to add another value)
routes:
Oral (1)
onset:
Within 30 minutes (IR) (1)
duration:
~12-24 hours (1)
halflife:
2-5 hours'"`UNIQ--ref-000002D9-QINU`"' (1)
bioavailability:
~100% (oral; food delays absorption, hence pre-meal dosing for IR)'"`UNIQ--ref-000002DA-QINU`"' (1)
pregnancy:
Avoid; switch to insulin. Hypoglycemia in newborn reported.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
[[USLegal:Prescription only|Rx-only]] in US (1)

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