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Medicines > generic: Hydroxychloroquine & fda max: 400 mg/d typical maintenance; weight-adjusted ceiling per ophthalmology guidance

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generic: (Click arrow to add another value)
brand:
Plaquenil; mostly prescribed generically (1)
classes:
[[:Category:Antimalarials|Antimalarial (4-aminoquinoline)]] (1) · [[:Category:DMARDs|DMARD]] (1) · [[:Category:Immunomodulators|Immunomodulator]] (1)
mechanism:
None (1)
uses:
'"`UNIQ--vote-000007E7-QINU`"', '"`UNIQ--vote-000007E8-QINU`"', '"`UNIQ--vote-000007E9-QINU`"', '"`UNIQ--vote-000007EA-QINU`"', '"`UNIQ--vote-000007EB-QINU`"' (1)
starting dose:
200-400 mg PO daily; '''dose by actual body weight ≤5 mg/kg/d''' to reduce retinopathy risk (AAO 2016 guideline) (1)
preparations:
200 mg tablets; 100 mg/5 mL suspension (1)
fda max: (Click arrow to add another value)
routes:
Oral (1)
onset:
Rheumatologic effect at 6-12 weeks (1)
duration:
Weeks (long half-life) (1)
halflife:
~40 days (terminal; reflects extensive tissue distribution)'"`UNIQ--ref-000007EC-QINU`"' (1)
bioavailability:
70-75% (oral)'"`UNIQ--ref-000007ED-QINU`"' (1)
pregnancy:
Long-considered safe in pregnancy for lupus and other rheumatologic indications; benefits typically outweigh.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
[[USLegal:Prescription only|Rx-only]] in US (1)

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