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Medicines > fda max: 8 tablets/d (300 mg tramadol / 2600 mg acetaminophen); 5-day duration limit per label & routes: Oral & onset: 30-60 minutes

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generic:
Tramadol / Acetaminophen (1)
brand:
Ultracet, Tramacet (1)
classes:
None (1)
mechanism:
None (1)
uses:
'"`UNIQ--vote-0000152F-QINU`"' (1)
starting dose:
2 tablets (75 mg tramadol / 650 mg acetaminophen) PO every 4-6 hours as needed; maximum 8 tablets/day for ≤5 days (1)
preparations:
Tramadol/acetaminophen 37.5/325 mg tablets (1)
fda max: (Click arrow to add another value)
routes: (Click arrow to add another value)
onset: (Click arrow to add another value)
duration:
4-6 hours (1)
halflife:
Tramadol ~5-7 hours (M1 metabolite ~9 hours); acetaminophen 1-3 hours'"`UNIQ--ref-00001530-QINU`"' (1)
bioavailability:
Tramadol ~75% (oral); acetaminophen 85-98%'"`UNIQ--ref-00001531-QINU`"' (1)
pregnancy:
Avoid; neonatal opioid withdrawal documented.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
[[USLegal:Schedule IV|Schedule IV controlled substance]] in US (tramadol was reclassified from non-controlled to Schedule IV in 2014 after recognition of dependence risk) (1)

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