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Medicines > fda max: 80 mg/d & onset : LDL lowering at 2 weeks, max by 4 weeks or Topical: irritation within days; acne improvement 6-12 weeks; oral APL response within days

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generic:
Pravastatin (1)
brand:
Pravachol (1)
classes:
[[:Category:Lipid-lowering_agents|Lipid-lowering agent]] (1) · [[:Category:Statins|Statin]] (1)
mechanism:
'"`UNIQ--vote-000003D1-QINU`"' SLCO1B1 polymorphism affects exposure but is most clinically actionable for simvastatin'"`UNIQ--ref-000003D2-QINU`"'. (1)
uses:
'"`UNIQ--vote-000003D3-QINU`"', '"`UNIQ--vote-000003D4-QINU`"' (1)
starting dose:
40 mg PO once daily (10-20 mg in elderly, hepatic impairment, or strong drug interactions) (1)
preparations:
10 mg, 20 mg, 40 mg, 80 mg tablets (1)
fda max: (Click arrow to add another value)
routes:
Oral (1)
onset: (Click arrow to add another value)
duration:
24 hours (1)
halflife:
~2-3 hours (parent); pharmacodynamic effect 24 hours via target turnover'"`UNIQ--ref-000003D5-QINU`"' (1)
bioavailability:
~17% (oral; food slightly reduces absorption)'"`UNIQ--ref-000003D6-QINU`"' (1)
pregnancy:
Previously Category X; FDA removed the blanket statin contraindication in pregnancy in 2021.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
[[USLegal:Prescription only|Rx-only]] in US (1)

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