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Medicines > generic : Codeine or Ticagrelor & fda max: 90 mg BID (acute year); 60 mg BID (chronic post-MI)

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generic: (Click arrow to add another value)
brand:
Brilinta (1)
classes:
[[:Category:Antiplatelet_agents|Antiplatelet agent]] (1) · [[:Category:Cyclopentyltriazolopyrimidines|Cyclopentyltriazolopyrimidine]] (1) · [[:Category:P2Y12_inhibitors|P2Y12 receptor inhibitor (reversible)]] (1)
mechanism:
None (1)
uses:
'"`UNIQ--vote-00000C8F-QINU`"', '"`UNIQ--vote-00000C90-QINU`"', '"`UNIQ--vote-00000C91-QINU`"' (1)
starting dose:
ACS/PCI: 180 mg PO loading dose, then 90 mg PO BID for 12 months; long-term post-MI: 60 mg BID (1)
preparations:
60, 90 mg tablets (1)
fda max: (Click arrow to add another value)
routes:
Oral (1)
onset:
Antiplatelet effect within 30 minutes of loading dose (faster than clopidogrel) (1)
duration:
12 hours (1)
halflife:
~7 hours (parent); ~9 hours (active AR-C124910XX metabolite, accounts for ~30-40% of activity)'"`UNIQ--ref-00000C92-QINU`"' (1)
bioavailability:
~36% (oral)'"`UNIQ--ref-00000C93-QINU`"' (1)
pregnancy:
Limited data; weigh against alternatives.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
[[USLegal:Prescription only|Rx-only]] in US. Carries a '''Boxed Warning''' for bleeding risk and against aspirin maintenance doses above 100 mg/d (reduces ticagrelor efficacy, per PLATO subgroup analysis)'"`UNIQ--ref-00000C94-QINU`"' (1)

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