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Medicines > fda max: Indication-dependent; 200-400 mg/d oral typical & routes : transdermal or vaginal

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generic:
Progesterone (micronized) (1)
brand:
Prometrium (oral), Endometrin (vaginal), Crinone (vaginal gel), Prochieve (1)
classes:
[[:Category:Hormone_replacement_therapy|Hormone replacement therapy]] (1) · [[:Category:Progestogens|Progestogen]] (1) · [[:Category:Sex_hormones|Sex hormone]] (1)
mechanism:
None (1)
uses:
'"`UNIQ--vote-00000722-QINU`"', '"`UNIQ--vote-00000723-QINU`"', '"`UNIQ--vote-00000724-QINU`"', '"`UNIQ--vote-00000725-QINU`"' (1)
starting dose:
HRT cyclic: 200 mg PO HS days 1-12 of each month; continuous: 100 mg PO daily; ART luteal support 100 mg vaginal TID or 90 mg gel daily (1)
preparations:
Oral 100, 200 mg capsules (peanut oil; check allergy); 100 mg vaginal insert (Endometrin); 4%, 8% vaginal gel (Crinone); IM 50 mg/mL (1)
fda max: (Click arrow to add another value)
routes: (Click arrow to add another value)
onset:
Sedation/dizziness within hours of oral dose; endometrial effects over days (1)
duration:
Oral: 8-12 hours; vaginal: 24+ hours; IM: days (1)
halflife:
~5-20 hours (oral micronized; highly variable)'"`UNIQ--ref-00000726-QINU`"' (1)
bioavailability:
Oral: very low (extensive first-pass); micronization improves uptake somewhat. Vaginal: high local effect with lower systemic levels (first-uterine-pass concentration)'"`UNIQ--ref-00000727-QINU`"' (1)
pregnancy:
None (1)
legal:
[[USLegal:Prescription only|Rx-only]] in US (1)

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