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Medicines > fda max: Indication-specific; high-dose IV regimens for encephalitis or disseminated disease & routes : rectal or topical

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generic:
Acyclovir (1)
brand:
Zovirax (1)
classes:
[[:Category:Anti-herpesvirus_agents|Anti-herpesvirus agent]] (1) · [[:Category:Antivirals|Antiviral]] (1) · [[:Category:Nucleoside_analogs|Nucleoside analog]] (1)
mechanism:
None (1)
uses:
'"`UNIQ--vote-00000909-QINU`"', '"`UNIQ--vote-0000090A-QINU`"', '"`UNIQ--vote-0000090B-QINU`"', '"`UNIQ--vote-0000090C-QINU`"', '"`UNIQ--vote-0000090D-QINU`"', '"`UNIQ--vote-0000090E-QINU`"' (1)
starting dose:
Initial genital herpes 400 mg PO TID × 7-10 days; episodic 800 mg TID × 2 days; suppression 400 mg BID; herpes zoster 800 mg 5×/day × 7 days; HSV encephalitis 10 mg/kg IV q8h × 14-21 days (1)
preparations:
200, 400, 800 mg tablets; 200 mg capsules; 200 mg/5 mL suspension; 500, 1000 mg IV vials; 5% cream and ointment (topical) (1)
fda max: (Click arrow to add another value)
routes: (Click arrow to add another value)
onset:
Symptom relief within 24-48 hours of starting episodic treatment (1)
duration:
8 hours per oral dose (1)
halflife:
~3 hours; significantly prolonged in renal impairment'"`UNIQ--ref-0000090F-QINU`"' (1)
bioavailability:
~20% (oral; valacyclovir prodrug raises this to ~55%)'"`UNIQ--ref-00000910-QINU`"' (1)
pregnancy:
Widely used in pregnancy for HSV/VZV indications; reassuring registry data.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
[[USLegal:Prescription only|Rx-only]] in US (1)

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