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Medicines > fda max: Limit topical to 10-day courses to reduce resistance pressure & routes : Intranasal or Topical

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generic:
Mupirocin (1)
brand:
Bactroban, Centany (1)
classes:
[[:Category:Antibacterials|Antibacterial]] (1) · [[:Category:Topical_antibiotics|Topical antibiotic]] (1)
mechanism:
'"`UNIQ--vote-000009FD-QINU`"' Active against gram-positive cocci including MRSA; the unique target underlies the absence of cross-resistance with other antibiotic classes. High-level resistance (plasmid-mediated mupA) is rising and limits prolonged or repeated use'"`UNIQ--ref-000009FE-QINU`"'. (1)
uses:
'"`UNIQ--vote-000009FF-QINU`"', '"`UNIQ--vote-00000A00-QINU`"', '"`UNIQ--vote-00000A01-QINU`"' (1)
starting dose:
Topical: apply small amount to affected area TID × 5-10 days; nasal: apply half the contents of a single-use tube into each nostril BID × 5 days (1)
preparations:
2% ointment; 2% cream; 2% nasal ointment (Bactroban Nasal) (1)
fda max: (Click arrow to add another value)
routes: (Click arrow to add another value)
onset:
Days (1)
duration:
Hours per application (1)
halflife:
Not meaningfully described for topical use'"`UNIQ--ref-00000A02-QINU`"' (1)
bioavailability:
Topical; minimal systemic absorption'"`UNIQ--ref-00000A03-QINU`"' (1)
pregnancy:
Generally considered safe; minimal systemic exposure.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
[[USLegal:Prescription only|Rx-only]] in US (1)

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