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Medicines > generic : Codeine or Prednisone & fda max: No fixed maximum; cumulative-dose toxicity drives all chronic decisions

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generic: (Click arrow to add another value)
brand:
Deltasone, Rayos (delayed-release); mostly prescribed generically (1)
classes:
[[:Category:Corticosteroids|Corticosteroid]] (1) · [[:Category:Glucocorticoids|Glucocorticoid (intermediate-acting)]] (1) · [[:Category:Immunosuppressants|Immunosuppressant]] (1)
mechanism:
None (1)
uses:
'"`UNIQ--vote-0000029D-QINU`"', '"`UNIQ--vote-0000029E-QINU`"', '"`UNIQ--vote-0000029F-QINU`"', '"`UNIQ--vote-000002A0-QINU`"', '"`UNIQ--vote-000002A1-QINU`"', '"`UNIQ--vote-000002A2-QINU`"' (1)
starting dose:
0.5-2 mg/kg/d divided or single morning dose for acute conditions; lowest effective dose for chronic conditions, with planned taper (1)
preparations:
1, 2.5, 5, 10, 20, 50 mg tablets; 5 mg/5 mL syrup; 5 mg/mL concentrate (1)
fda max: (Click arrow to add another value)
routes:
Oral (1)
onset:
Hours (1)
duration:
Biologic half-life ~12-36 hours (intermediate-acting); plasma half-life shorter (1)
halflife:
Plasma 3-4 hours; biologic ~12-36 hours'"`UNIQ--ref-000002A3-QINU`"' (1)
bioavailability:
70-80% (oral)'"`UNIQ--ref-000002A4-QINU`"' (1)
pregnancy:
Used when benefits outweigh risk; oral cleft signal in first-trimester exposure is debated and small in absolute terms.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
[[USLegal:Prescription only|Rx-only]] in US (1)

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