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Medicines > generic : 25N-NBOMe or Thyroid (desiccated) & fda max: No fixed maximum; titrated to TSH target

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generic: (Click arrow to add another value)
brand:
Armour Thyroid, NP Thyroid, Nature-Throid, WP Thyroid (1)
classes:
[[:Category:Hormone_replacement|Hormone replacement]] (1) · [[:Category:Thyroid_hormones|Thyroid hormone]] (1)
mechanism:
'"`UNIQ--vote-00000032-QINU`"' Brand-to-brand and lot-to-lot variability in T3:T4 ratio is greater than with synthetic levothyroxine, which is why endocrine guidelines prefer the synthetic'"`UNIQ--ref-00000033-QINU`"'. (1)
uses:
'"`UNIQ--vote-00000034-QINU`"', '"`UNIQ--vote-00000035-QINU`"' (1)
starting dose:
30 mg PO daily (1/2 grain); titrate by TSH at 6-8 weeks; 60 mg desiccated thyroid is approximately equivalent to 88-100 mcg levothyroxine (1)
preparations:
15, 30, 60, 90, 120, 180, 240, 300 mg tablets (1/4 to 5 grains; 1 grain = 60 mg) (1)
fda max: (Click arrow to add another value)
routes:
Oral (1)
onset:
TSH normalization 4-8 weeks (1)
duration:
Steady-state at 4-6 weeks (1)
halflife:
T4 ~7 days; T3 ~1 day'"`UNIQ--ref-00000036-QINU`"' (1)
bioavailability:
Variable; reduced by food, calcium, iron, PPIs'"`UNIQ--ref-00000037-QINU`"' (1)
pregnancy:
Synthetic levothyroxine is the standard-of-care in pregnancy; desiccated thyroid use in pregnancy is not well studied<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
[[USLegal:Prescription only|Rx-only]] in US (1)

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