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Medicines > fda max: Topical: nightly; oral APL: 45 mg/m²/d & routes : IV/IM (Buprenex). Oral swallowed: very low bioavailability due to first-pass; not therapeutic. or Topical

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generic:
Tretinoin (all-trans retinoic acid, ATRA) (1)
brand:
Retin-A, Renova, Atralin, Avita, Tretin-X, Refissa, Altreno; Vesanoid (oral, APL) (1)
classes:
APL)]] (1) · [[:Category:Antineoplastics|Antineoplastic (oral (1) · [[:Category:Retinoids|Retinoid]] (1) · [[:Category:Topical_retinoids|Topical retinoid]] (1)
mechanism:
None (1)
uses:
'"`UNIQ--vote-00000BA0-QINU`"', '"`UNIQ--vote-00000BA1-QINU`"', '"`UNIQ--vote-00000BA2-QINU`"' (1)
starting dose:
Topical: pea-sized amount to dry face at bedtime, building from 2-3×/week to nightly as tolerated; oral APL: 45 mg/m²/d in divided doses (1)
preparations:
Topical 0.01-0.1% creams, gels, micropsheres, lotions; oral 10 mg capsules (Vesanoid) (1)
fda max: (Click arrow to add another value)
routes: (Click arrow to add another value)
onset:
Topical: irritation within days; acne improvement 6-12 weeks; oral APL response within days (1)
duration:
N/A (1)
halflife:
~0.5-2 hours (oral)'"`UNIQ--ref-00000BA3-QINU`"' (1)
bioavailability:
Topical: minimal systemic absorption with normal skin; oral: variable, induced metabolism with repeated dosing'"`UNIQ--ref-00000BA4-QINU`"' (1)
pregnancy:
None (1)
legal:
[[USLegal:Prescription only|Rx-only]] in US (1)

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