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Medicines > fda max: None & routes : IM or buccal); refined cocaine has its own profile

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generic:
Coca (1) · Haloperidol (1)
brand:
''Erythroxylum coca'', ''E. novogranatense'' (1) · Haldol, Serenace, Haldol Decanoate (1)
classes:
Antiemetic (1) · Excitantia (1) · Plant Medicine (1) · Typical antipsychotic (1)
mechanism:
High-affinity D2 receptor antagonist (1) · Primary alkaloid is cocaine, a tropane that blocks reuptake of dopamine and norepinephrine (and serotonin). At low oral doses from leaf chewing, the slow release favors NE-mediated alertness over DA-mediated euphoria. (1)
uses:
Schizophrenia, acute psychosis, agitation, delirium, Tourette syndrome, severe nausea (1) · '"`UNIQ--vote-0000000C-QINU`"', '"`UNIQ--vote-0000000D-QINU`"', '"`UNIQ--vote-0000000E-QINU`"', '"`UNIQ--vote-0000000F-QINU`"' (1)
starting dose:
None (2)
preparations:
None (1) · Leaves chewed with a pinch of slaked lime (the lime converts cocaine HCl to freebase for buccal absorption); also drunk as tea (''mate de coca'') (1)
fda max: (Click arrow to add another value)
routes: (Click arrow to add another value)
onset:
None (1) · PO 1–2 h; IM 30–60 min; IV 5–20 min (1)
duration:
None (1) · 12–24 h (oral); decanoate IM 3–4 weeks (1)
halflife:
None (1) · 14–26 h (oral); ~3 weeks (decanoate) (1)
bioavailability:
None (1) · ~60–70% (oral) (1)
pregnancy:
None (1) · Category C (1)
legal:
Leaves legal in Bolivia, Peru, Colombia; cocaine internationally controlled (1) · Rx-only (1)

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