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Drilldown: Medicines

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Medicines > generic : 1,4-Butanediol or 2-AI or Psilocybin

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generic: (Click arrow to add another value)
brand:
None (2) · COMP360 (Compass Pathways, investigational synthesized clinical formulation) (1)
classes:
GABAergic (1) · Research material (2) · Stimulant (1) · [[:Category:Classical Psychedelics (Serotonergic)|Serotonergic psychedelic]] (1) · [[:Category:Psychedelics|Psychedelic]] (1) · [[:Category:Tryptamines|Tryptamine]] (1)
mechanism:
Alpha-methylated amphetamine analogue; norepinephrine releasing agent (1) · Prodrug of GHB (1) · Prodrug to [[Psilocin|psilocin]] (4-hydroxy-N,N-dimethyltryptamine), a partial agonist at the [[Receptor:5-HT2A|5-HT2A]] serotonin receptor; the action that defines the classical-psychedelic mechanism (1)
uses:
None (2) · (investigational) '"`UNIQ--vote-000000EF-QINU`"', '"`UNIQ--vote-000000F0-QINU`"', '"`UNIQ--vote-000000F1-QINU`"', '"`UNIQ--vote-000000F2-QINU`"', '"`UNIQ--vote-000000F3-QINU`"' (1)
starting dose:
None (2) · Modern clinical-trial standard: 25 mg synthesized psilocybin, single oral dose with psychological support (1)
preparations:
None (2) · Synthesized psilocybin capsules (COMP360 and other investigational formulations); dried whole [[Psilocybe|Psilocybe]] mushrooms (variable potency, no legal supply chain in most jurisdictions); psilocybin truffles (Psilocybe sclerotia, legal in the Netherlands) (1)
fda max:
None (2) · Not FDA-approved; clinical-trial protocols use up to 30 mg in adult investigational dosing (1)
routes:
None (2) · Oral (1)
onset:
None (2) · 20-45 min subjective onset; psilocin formation from psilocybin requires intestinal and hepatic alkaline phosphatase (1)
duration:
None (2) · 4-6 hours (1)
halflife:
None (2) · Psilocin: ~2-3 h; psilocybin itself is a prodrug, dephosphorylated within minutes of absorption (1)
bioavailability:
None (2) · Oral bioavailability of psilocin from administered psilocybin approximately 50% (1)
pregnancy:
None (2) · Not studied in human pregnancy; no approved clinical use in any population (1)
legal:
None (3)

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