Drilldown: Medicines

None · Codeine · 1,4-Butanediol · 1B-LSD · 1cP-LSD · 1P-LSD · 1V-LSD · 2-AI · 2-FA · 2-FDCK · 2-FMA · 25B-NBOH · 25B-NBOMe · 25C-NBOH · 25C-NBOMe · 25I-NBOH · 25I-NBOMe · 25N-NBOMe · 2C-B · 2C-B-FLY

Other values:

Search

None (2) · ''Erythroxylum coca'', ''E. novogranatense'' (1) · (multiple, generic dominant) (1)

Analgesic (2) · Excitantia (1) · GABAergic (1) · Opioid (2) · Plant Medicine (1) · Prodrug (1) · Research material (1)

Mu-opioid receptor agonist; prodrug (metabolized to morphine) (1) · Primary alkaloid is cocaine, a tropane that blocks reuptake of dopamine and norepinephrine (and serotonin). At low oral doses from leaf chewing, the slow release favors NE-mediated alertness over DA-mediated euphoria. (1) · Prodrug of GHB (1) · Prodrug; converted to [[Morphine|morphine]] by [[Enzyme:CYP2D6|CYP2D6]] for analgesic action. (1)

None (2) · Mild to moderate pain; cough suppression (low-dose). (1) · '"`UNIQ--vote-0000000C-QINU`"', '"`UNIQ--vote-0000000D-QINU`"', '"`UNIQ--vote-0000000E-QINU`"', '"`UNIQ--vote-0000000F-QINU`"' (1)

None (3) · Adult: 15–60 mg every 4 hours as needed. (1)

None (2) · Leaves chewed with a pinch of slaked lime (the lime converts cocaine HCl to freebase for buccal absorption); also drunk as tea (''mate de coca'') (1) · Tablet (15, 30, 60 mg); oral solution; combination products (with [[Acetaminophen|acetaminophen]] or ibuprofen). (1)

None (3) · 360 mg/day (1)

None (2) · buccal); refined cocaine has its own profile (1) · Oral (leaf (1) · PO (only formulation marketed in the US). (1)

None (3) · 30–60 min (PO) (1)

None (3) · 4–6 hours (1)

None (3) · 2.5–3 hours (1)

None (3) · ~50% (variable, CYP2D6-dependent for analgesic effect). (1)

None (3) · Avoid; risk of neonatal opioid withdrawal with chronic use; UM-mother breastfeeding contraindicated. (1)

None (2) · Leaves legal in Bolivia, Peru, Colombia; cocaine internationally controlled (1) · US Schedule II (single-entity); Schedule III–V (combination products by content). (1)