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Medicines > generic : 1P-LSD or Methimazole (thiamazole)

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generic: (Click arrow to add another value)
brand:
None (1) · Tapazole; outside US Mercazole (1)
classes:
Classic Psychedelic (1) · Lysergamide (1) · Research material (1) · [[:Category:Antithyroid_agents|Antithyroid agent]] (1) · [[:Category:Thionamides|Thionamide]] (1)
mechanism:
Prodrug of LSD; 5-HT2A agonist (1) · '"`UNIQ--vote-00000ECD-QINU`"' Agranulocytosis is the most-feared adverse effect (~0.3%, usually first 90 days of treatment; warn patients to seek urgent CBC for fever or severe sore throat). Hepatotoxicity is class-recognized but more often associated with PTU'"`UNIQ--ref-00000ECE-QINU`"'. (1)
uses:
None (1) · '"`UNIQ--vote-00000ECF-QINU`"', '"`UNIQ--vote-00000ED0-QINU`"', '"`UNIQ--vote-00000ED1-QINU`"', '"`UNIQ--vote-00000ED2-QINU`"' (1)
starting dose:
None (1) · 10-40 mg PO daily depending on hyperthyroidism severity; titrate by clinical and biochemical response (target TSH/free T4) (1)
preparations:
None (1) · 5, 10 mg tablets (1)
fda max:
None (1) · 60 mg/d typical (1)
routes:
None (1) · Oral (1)
onset:
None (1) · Biochemical improvement within 2-4 weeks; full euthyroid state 6-12 weeks (1)
duration:
None (1) · 24 hours (1)
halflife:
None (1) · ~4-6 hours (plasma); intrathyroidal accumulation gives a much longer functional duration'"`UNIQ--ref-00000ED3-QINU`"' (1)
bioavailability:
None (1) · ~93% (oral)'"`UNIQ--ref-00000ED4-QINU`"' (1)
pregnancy:
None (2)
legal:
None (1) · [[USLegal:Prescription only|Rx-only]] in US (1)

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