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Medicines > generic : 1cP-LSD or 2C-B or Spironolactone

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generic: (Click arrow to add another value)
brand:
None (1) · Aldactone, CaroSpir (1) · Nexus, Eroxan (historical, late-1980s through mid-1990s) (1)
classes:
2C-x series (1) · Classic Psychedelic (1) · Lysergamide (1) · Phenethylamine (1) · Psychedelic (1) · Research material (1) · [[:Category:Aldosterone_antagonists|Mineralocorticoid (aldosterone) receptor antagonist]] (1) · [[:Category:Antiandrogens|Antiandrogen]] (1) · [[:Category:Potassium-sparing_diuretics|Potassium-sparing diuretic]] (1)
mechanism:
None (1) · 5-HT2A partial agonist (1) · Prodrug of LSD; 5-HT2A agonist (1)
uses:
None (2) · '"`UNIQ--vote-0000034F-QINU`"', '"`UNIQ--vote-00000350-QINU`"', '"`UNIQ--vote-00000351-QINU`"', '"`UNIQ--vote-00000352-QINU`"', '"`UNIQ--vote-00000353-QINU`"' (1)
starting dose:
None (2) · 25 mg PO once daily for HFrEF and primary aldosteronism; up to 100 mg/d for ascites; 50-200 mg/d for hirsutism (1)
preparations:
None (2) · 25 mg, 50 mg, 100 mg tablets; 25 mg/5 mL oral suspension (CaroSpir) (1)
fda max:
None (2) · 400 mg/d (acute primary aldosteronism diagnosis); 100-200 mg/d typical chronic (1)
routes:
None (1) · insufflated (1) · Oral (2) · PR (1)
onset:
None (1) · 45-75 min (oral) (1) · Natriuresis at 2-3 days; endocrine effects (gynecomastia, antiandrogen action) over weeks (1)
duration:
None (1) · 4-8 h (1) · Variable; biologically active metabolite carries effect beyond plasma half-life (1)
halflife:
None (1) · 1.4 hours (parent); 13-24 hours for active metabolite canrenone'"`UNIQ--ref-00000354-QINU`"' (1) · Not well characterized (1)
bioavailability:
None (1) · Not well characterized (1) · ~70% (oral; bioavailability and absorption are improved with food)'"`UNIQ--ref-00000355-QINU`"' (1)
pregnancy:
None (1) · Avoid in pregnancy; antiandrogen effects can feminize a male fetus.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1) · Not established (1)
legal:
None (1) · [[USLegal:DEA Schedule I|Schedule I]] (United States) (1) · [[USLegal:Prescription only|Rx-only]] in US (1)

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