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Medicines > generic : 1cP-LSD or Codeine or Liraglutide

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generic: (Click arrow to add another value)
brand:
None (2) · (multiple, generic dominant) (1) · Victoza (T2DM), Saxenda (obesity) (1)
classes:
Analgesic (2) · Classic Psychedelic (1) · Lysergamide (1) · Opioid (2) · Prodrug (1) · Research material (1) · [[GLP-1 receptor agonist]] · [[Antidiabetic medicines|Antidiabetic]] · [[Anti-obesity medicines|Anti-obesity]] · [[Cardiovascular risk reduction]] agent (1)
mechanism:
Mu-opioid receptor agonist; prodrug (metabolized to morphine) (1) · Once-daily agonist of the [[GLP-1 receptor]]. (1) · Prodrug of LSD; 5-HT2A agonist (1) · Prodrug; converted to [[Morphine|morphine]] by [[Enzyme:CYP2D6|CYP2D6]] for analgesic action. (1)
uses:
None (2) · Mild to moderate pain; cough suppression (low-dose). (1) · [[Type 2 diabetes mellitus]] (incl. pediatric ≥10 y) · [[Obesity]] (incl. pediatric ≥12 y) · [[Cardiovascular risk reduction]] in T2DM (1)
starting dose:
None (2) · Adult: 15–60 mg every 4 hours as needed. (1) · Victoza: 0.6 mg SC daily × 1 wk'"`UNIQ--ref-00000181-QINU`"' · Saxenda: 0.6 mg SC daily × 1 wk'"`UNIQ--ref-00000182-QINU`"' (1)
preparations:
None (2) · Pre-filled multi-dose pen (3 mL): Victoza 6 mg/mL (0.6 / 1.2 / 1.8 mg per day);'"`UNIQ--ref-00000183-QINU`"' Saxenda 6 mg/mL (0.6 / 1.2 / 1.8 / 2.4 / 3.0 mg per day)'"`UNIQ--ref-00000184-QINU`"' (1) · Tablet (15, 30, 60 mg); oral solution; combination products (with [[Acetaminophen|acetaminophen]] or ibuprofen). (1)
fda max:
None (2) · 1.8 mg/day SC (Victoza, T2DM)'"`UNIQ--ref-00000185-QINU`"' · 3.0 mg/day SC (Saxenda, obesity)'"`UNIQ--ref-00000186-QINU`"' (1) · 360 mg/day (1)
routes:
None (2) · PO (only formulation marketed in the US). (1) · Subcutaneous (abdomen (1) · thigh (1) · upper arm); same time each day (1) · with or without food'"`UNIQ--ref-00000187-QINU`"' (1)
onset:
None (2) · 30–60 min (PO) (1) · Glycemic effect within days; weight effect over weeks to months'"`UNIQ--ref-00000188-QINU`"' (1)
duration:
None (2) · 4–6 hours (1) · ~24 h (daily dosing)'"`UNIQ--ref-00000189-QINU`"' (1)
halflife:
None (2) · 2.5–3 hours (1) · ~13 hours'"`UNIQ--ref-0000018A-QINU`"' (1)
bioavailability:
None (2) · SC ~55%'"`UNIQ--ref-0000018B-QINU`"' (1) · ~50% (variable, CYP2D6-dependent for analgesic effect). (1)
pregnancy:
None (2) · Avoid. Discontinue before planned pregnancy.'"`UNIQ--ref-0000018C-QINU`"' (1) · Avoid; risk of neonatal opioid withdrawal with chronic use; UM-mother breastfeeding contraindicated. (1)
legal:
None (2) · Rx-only;'"`UNIQ--ref-0000018D-QINU`"' not a controlled substance (1) · US Schedule II (single-entity); Schedule III–V (combination products by content). (1)

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