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Medicines > generic : 1cP-LSD or Methylprednisolone

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generic: (Click arrow to add another value)
brand:
None (1) · Medrol (oral), Solu-Medrol (IV/IM), Depo-Medrol (depot injection) (1)
classes:
Classic Psychedelic (1) · Lysergamide (1) · Research material (1) · [[:Category:Corticosteroids|Corticosteroid]] (1) · [[:Category:Glucocorticoids|Glucocorticoid (intermediate-acting)]] (1) · [[:Category:Immunosuppressants|Immunosuppressant]] (1)
mechanism:
Prodrug of LSD; 5-HT2A agonist (1) · '"`UNIQ--vote-00000860-QINU`"' Activates the glucocorticoid receptor to broadly remodel inflammatory, immune, and metabolic transcription. Unlike prednisone, it does not require hepatic activation, making it the preferred oral choice in severe hepatic dysfunction'"`UNIQ--ref-00000861-QINU`"'. (1)
uses:
None (1) · '"`UNIQ--vote-00000862-QINU`"', '"`UNIQ--vote-00000863-QINU`"', '"`UNIQ--vote-00000864-QINU`"', '"`UNIQ--vote-00000865-QINU`"', '"`UNIQ--vote-00000866-QINU`"' (1)
starting dose:
None (1) · PO Medrol Dosepak (5-day taper from 24 mg to 4 mg) is the prototypic short-course outpatient regimen; IV pulse 1 g daily for 3-5 days for MS relapse; intra-articular 4-80 mg per joint q1-5 weeks (1)
preparations:
None (1) · 2, 4, 8, 16, 32 mg oral tablets; 40, 125, 500, 1000 mg IV vials; Depo-Medrol 20, 40, 80 mg/mL IM depot (1)
fda max:
None (1) · Indication-specific (1)
routes:
None (1) · IM (1) · intra-articular (1) · intrathecal (rare and controversial) (1) · IV (1) · Oral (1)
onset:
None (1) · IV pulse: hours; PO: hours; intra-articular: days (1)
duration:
None (1) · Biologic 12-36 hours (intermediate-acting); Depo-Medrol depot weeks (1)
halflife:
None (1) · Plasma 2-3 hours; biologic ~18-36 hours'"`UNIQ--ref-00000867-QINU`"' (1)
bioavailability:
None (1) · ~80-99% (oral)'"`UNIQ--ref-00000868-QINU`"' (1)
pregnancy:
None (1) · Use when benefits outweigh; small association with oral clefts in first trimester debated.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
None (1) · [[USLegal:Prescription only|Rx-only]] in US (1)

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