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Drilldown: Medicines

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Medicines > generic : 1cP-LSD or Topiramate

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generic: (Click arrow to add another value)
brand:
None (1) · Topamax (IR), Trokendi XR, Qudexy XR, Eprontia (oral solution); component of Qsymia (with phentermine) (1)
classes:
Classic Psychedelic (1) · Lysergamide (1) · Research material (1) · [[:Category:Anticonvulsants|Anticonvulsant]] (1) · [[:Category:Migraine prophylactics|Migraine prophylactic]] (1) · [[:Category:Sodium channel blockers|Sodium channel blocker]] (1) · [[:Category:Weight loss medicines|Weight loss medicine]] (1)
mechanism:
None (1) · Prodrug of LSD; 5-HT2A agonist (1)
uses:
None (1) · '"`UNIQ--vote-00000021-QINU`"', '"`UNIQ--vote-00000022-QINU`"', '"`UNIQ--vote-00000023-QINU`"', '"`UNIQ--vote-00000024-QINU`"', '"`UNIQ--vote-00000025-QINU`"', '"`UNIQ--vote-00000026-QINU`"', '"`UNIQ--vote-00000027-QINU`"' (1)
starting dose:
None (1) · Migraine: 25 mg PO at bedtime, titrate by 25 mg weekly to target 100 mg/day divided BID. Seizures: 25-50 mg/day, titrate weekly to 200-400 mg/day divided BID (1)
preparations:
None (1) · IR tablets 25, 50, 100, 200 mg; sprinkle capsules 15, 25 mg; Trokendi XR capsules 25, 50, 100, 200 mg; Qudexy XR capsules; Eprontia oral solution 25 mg/mL (1)
fda max:
None (1) · 1600 mg/day (theoretical seizure dosing); practical use 400 mg/day for seizures, 100-200 mg/day for migraine prophylaxis (1)
routes:
None (1) · Oral (1)
onset:
None (1) · Anticonvulsant effect within days at therapeutic level; migraine prophylaxis effect emerges over 2-3 months (1)
duration:
None (1) · 12-24 hours (IR BID); 24 hours (ER once-daily) (1)
halflife:
None (1) · ~21 hours'"`UNIQ--ref-00000028-QINU`"' (1)
bioavailability:
None (1) · ~80% (oral)'"`UNIQ--ref-00000029-QINU`"' (1)
pregnancy:
None (1) · '''Substantial teratogenic risk''' including cleft lip/palate, hypospadias, and growth restriction (pregnancy registry data clear); effective contraception and pre-pregnancy counseling are required in reproductive-age patients'"`UNIQ--ref-0000002A-QINU`"' (1)
legal:
None (1) · [[USLegal:Prescription only|Rx-only]] in US. Not a controlled substance'"`UNIQ--ref-0000002B-QINU`"' (1)

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