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Medicines > generic : 2-AI or 2-FDCK or Citalopram

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generic: (Click arrow to add another value)
brand:
None (2) · Celexa (1)
classes:
Dissociative (1) · Research material (2) · Stimulant (1) · [[:Category:Antidepressants|Antidepressant]] (1) · [[:Category:SSRIs|Selective serotonin reuptake inhibitor (SSRI)]] (1)
mechanism:
Alpha-methylated amphetamine analogue; norepinephrine releasing agent (1) · NMDA antagonist; fluorinated ketamine analogue (1) · '"`UNIQ--vote-0000001D-QINU`"' CYP2C19 + CYP3A4 metabolism, with CPIC PGx guidance: poor CYP2C19 metabolizers have ~3-fold higher exposure and benefit from a lower starting dose; ultrarapid metabolizers may have inadequate response'"`UNIQ--ref-0000001E-QINU`"'. (1)
uses:
None (2) · '"`UNIQ--vote-0000001F-QINU`"', '"`UNIQ--vote-00000020-QINU`"', '"`UNIQ--vote-00000021-QINU`"', '"`UNIQ--vote-00000022-QINU`"', '"`UNIQ--vote-00000023-QINU`"', '"`UNIQ--vote-00000024-QINU`"', '"`UNIQ--vote-00000025-QINU`"' (1)
starting dose:
None (2) · 20 mg PO once daily; titrate to 40 mg/day after 1 week if tolerated. Elderly (>60) and hepatic impairment: 20 mg/day ceiling (1)
preparations:
None (2) · Tablets 10, 20, 40 mg; oral solution 10 mg/5 mL (1)
fda max:
None (2) · '''20 mg/day in adults >60 years''' per FDA's 2011-2012 QT-prolongation warning; 40 mg/day in adults ≤60 (1)
routes:
None (2) · Oral (1)
onset:
None (2) · Antidepressant effect over 1-2 weeks; full clinical effect 4-6 weeks (1)
duration:
None (2) · 24 hours (once-daily dosing) (1)
halflife:
None (2) · ~35 hours'"`UNIQ--ref-00000026-QINU`"' (1)
bioavailability:
None (2) · ~80% (oral)'"`UNIQ--ref-00000027-QINU`"' (1)
pregnancy:
None (2) · Observational signal for persistent pulmonary hypertension of the newborn (small absolute risk) and neonatal adaptation syndrome with third-trimester exposure.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
None (2) · [[USLegal:Prescription only|Rx-only]] in US. Carries the antidepressant '''Boxed Warning''' for suicidality in children, adolescents, and young adults'"`UNIQ--ref-00000028-QINU`"' (1)

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