Drilldown: Medicines

None · Codeine · 1,4-Butanediol · 1B-LSD · 1cP-LSD · 1P-LSD · 1V-LSD · 2-AI · 2-FA · 2-FDCK · 2-FMA · 25B-NBOH · 25B-NBOMe · 25C-NBOH · 25C-NBOMe · 25I-NBOH · 25I-NBOMe · 25N-NBOMe · 2C-B · 2C-B-FLY

Other values:

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None (2) · Mysoline (1)

Amphetamine (1) · Research material (2) · Stimulant (2) · [[:Category:Anticonvulsants|Anticonvulsant]] (1) · [[:Category:Barbiturates|Barbiturate (parent compound)]] (1) · [[:Category:Tremor medicines|Tremor medicine]] (1)

Alpha-methylated amphetamine analogue; norepinephrine releasing agent (1) · Monoamine releasing agent (1) · '"`UNIQ--vote-00000013-QINU`"' Strong CYP3A4 induction via the phenobarbital metabolite produces many interactions (reduces oral contraceptives, warfarin, many psychotropics). Essential-tremor efficacy is the unique pharmacological selling point'"`UNIQ--ref-00000014-QINU`"'. (1)

None (2) · '"`UNIQ--vote-00000015-QINU`"', '"`UNIQ--vote-00000016-QINU`"' (1)

None (2) · Seizures: 100-125 mg PO at bedtime x 3 days, then BID, then TID, escalating to 750-1500 mg/day. Essential tremor: 25-50 mg PO at bedtime, titrate slowly to 250-750 mg/day (1)

None (2) · Tablets 50, 250 mg (1)

None (2) · 2 g/day (seizures); typically much lower for essential tremor (1)

None (2) · Oral (1)

None (2) · Anticonvulsant effect emerges with slow titration over weeks; tremor effect over weeks (1)

None (2) · BID-TID dosing (1)

None (2) · Primidone 5-15 hours; '''phenobarbital active metabolite 50-150 hours'''; PEMA (phenylethylmalonamide) active metabolite 16 hours'"`UNIQ--ref-00000017-QINU`"' (1)

None (2) · ~90% (oral)'"`UNIQ--ref-00000018-QINU`"' (1)

None (2) · Substantial teratogenic signal (barbiturate class effects including neonatal withdrawal and hemorrhagic disease of newborn).<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)

None (2) · [[USLegal:Prescription only|Rx-only]] in US. '''Federally non-controlled despite being a barbiturate''', a paradoxical situation given that its primary active metabolite phenobarbital is Schedule IV'"`UNIQ--ref-00000019-QINU`"' (1)