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Medicines > generic : 2-AI or 25C-NBOH or Hydroxyzine (hydrochloride; pamoate salt)

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generic: (Click arrow to add another value)
brand:
None (2) · Vistaril (pamoate), Atarax (HCl, discontinued in US as brand) (1)
classes:
Classic Psychedelic (1) · Phenethylamine (1) · Research material (2) · Stimulant (1) · [[:Category:Antihistamines|First-generation antihistamine]] (1) · [[:Category:Antipruritics|Antipruritic]] (1) · [[:Category:Anxiolytics|Anxiolytic]] (1) · [[:Category:Sleep aids|Sleep aid (off-label)]] (1)
mechanism:
Alpha-methylated amphetamine analogue; norepinephrine releasing agent (1) · Potent 5-HT2A agonist (1) · '"`UNIQ--vote-0000001D-QINU`"' '''QT prolongation''' risk at high doses prompted the FDA's 2015 caution against use in patients with prolonged QT or with concurrent QT-prolonging medicines'"`UNIQ--ref-0000001E-QINU`"'. (1)
uses:
None (2) · '"`UNIQ--vote-0000001F-QINU`"', '"`UNIQ--vote-00000020-QINU`"', '"`UNIQ--vote-00000021-QINU`"', '"`UNIQ--vote-00000022-QINU`"', '"`UNIQ--vote-00000023-QINU`"', '"`UNIQ--vote-00000024-QINU`"', '"`UNIQ--vote-00000025-QINU`"' (1)
starting dose:
None (2) · Anxiety: 25-50 mg PO QID. Pruritus: 25 mg PO TID-QID. Insomnia: 25-50 mg PO at bedtime. Pediatric: 50-100 mg/day divided (1)
preparations:
None (2) · Tablets 10, 25, 50 mg (HCl); capsules 25, 50, 100 mg (pamoate); oral suspension 25 mg/5 mL; injection 25, 50 mg/mL (IM only, never IV) (1)
fda max:
None (2) · 400 mg/day theoretical; in practice rarely exceeds 200 mg/day (1)
routes:
None (2) · intramuscular (1) · Oral (1)
onset:
None (2) · 15-30 minutes (oral) (1)
duration:
None (2) · 4-6 hours (1)
halflife:
None (2) · 14-25 hours (longer in elderly and hepatic impairment)'"`UNIQ--ref-00000026-QINU`"' (1)
bioavailability:
None (2) · ~80% (oral)'"`UNIQ--ref-00000027-QINU`"' (1)
pregnancy:
None (2) · Limited human data; older agent with substantial use experience; some signal for first-trimester exposure but not conclusive.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
None (2) · [[USLegal:Prescription only|Rx-only]] in US. Not a controlled substance, which is a meaningful clinical advantage over the benzodiazepine alternatives for short-term anxiety'"`UNIQ--ref-00000028-QINU`"' (1)

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