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Drilldown: Medicines

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Medicines > generic : 2-AI or 2C-B or Ticagrelor

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generic: (Click arrow to add another value)
brand:
None (1) · Brilinta (1) · Nexus, Eroxan (historical, late-1980s through mid-1990s) (1)
classes:
2C-x series (1) · Phenethylamine (1) · Psychedelic (1) · Research material (1) · Stimulant (1) · [[:Category:Antiplatelet_agents|Antiplatelet agent]] (1) · [[:Category:Cyclopentyltriazolopyrimidines|Cyclopentyltriazolopyrimidine]] (1) · [[:Category:P2Y12_inhibitors|P2Y12 receptor inhibitor (reversible)]] (1)
mechanism:
None (1) · 5-HT2A partial agonist (1) · Alpha-methylated amphetamine analogue; norepinephrine releasing agent (1)
uses:
None (2) · '"`UNIQ--vote-00000C8F-QINU`"', '"`UNIQ--vote-00000C90-QINU`"', '"`UNIQ--vote-00000C91-QINU`"' (1)
starting dose:
None (2) · ACS/PCI: 180 mg PO loading dose, then 90 mg PO BID for 12 months; long-term post-MI: 60 mg BID (1)
preparations:
None (2) · 60, 90 mg tablets (1)
fda max:
None (2) · 90 mg BID (acute year); 60 mg BID (chronic post-MI) (1)
routes:
None (1) · insufflated (1) · Oral (2) · PR (1)
onset:
None (1) · 45-75 min (oral) (1) · Antiplatelet effect within 30 minutes of loading dose (faster than clopidogrel) (1)
duration:
None (1) · 12 hours (1) · 4-8 h (1)
halflife:
None (1) · Not well characterized (1) · ~7 hours (parent); ~9 hours (active AR-C124910XX metabolite, accounts for ~30-40% of activity)'"`UNIQ--ref-00000C92-QINU`"' (1)
bioavailability:
None (1) · Not well characterized (1) · ~36% (oral)'"`UNIQ--ref-00000C93-QINU`"' (1)
pregnancy:
None (1) · Limited data; weigh against alternatives.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1) · Not established (1)
legal:
None (1) · [[USLegal:DEA Schedule I|Schedule I]] (United States) (1) · [[USLegal:Prescription only|Rx-only]] in US. Carries a '''Boxed Warning''' for bleeding risk and against aspirin maintenance doses above 100 mg/d (reduces ticagrelor efficacy, per PLATO subgroup analysis)'"`UNIQ--ref-00000C94-QINU`"' (1)

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