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Medicines > generic : 2-AI or Betamethasone (valerate, dipropionate, sodium phosphate, acetate)

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generic: (Click arrow to add another value)
brand:
None (1) · Celestone (oral/injectable), Diprolene/Diprosone (topical), Luxiq (foam), Celestone Soluspan (depot IM) (1)
classes:
high-potency)]] (1) · Research material (1) · Stimulant (1) · [[:Category:Corticosteroids|Corticosteroid]] (1) · [[:Category:Glucocorticoids|Glucocorticoid (long-acting (1) · [[:Category:Topical_corticosteroids|Topical corticosteroid (high-to-super-high potency depending on ester)]] (1)
mechanism:
Alpha-methylated amphetamine analogue; norepinephrine releasing agent (1) · '"`UNIQ--vote-00001014-QINU`"' Activates the glucocorticoid receptor to broadly remodel inflammatory, immune, and metabolic transcription. The dipropionate, valerate, and augmented dipropionate ester forms determine topical potency (high to super-high)'"`UNIQ--ref-00001015-QINU`"'. (1)
uses:
None (1) · '"`UNIQ--vote-00001016-QINU`"', '"`UNIQ--vote-00001017-QINU`"', '"`UNIQ--vote-00001018-QINU`"', '"`UNIQ--vote-00001019-QINU`"' (1)
starting dose:
None (1) · Antenatal: Celestone Soluspan 12 mg IM q24h × 2 doses; topical: pea-sized amount BID; intra-articular varies by joint (1)
preparations:
None (1) · 0.6 mg/5 mL oral solution; Celestone Soluspan 6 mg/mL IM/IA (mix of sodium phosphate + acetate); 0.05% and 0.1% topical cream/ointment/lotion/foam (various salts); augmented betamethasone 0.05% (super-high potency) (1)
fda max:
None (1) · Indication-specific (1)
routes:
None (1) · IA (1) · IM (1) · Oral (1) · topical (1)
onset:
None (1) · Hours (1)
duration:
None (1) · Biologic 36-54 hours (long-acting) (1)
halflife:
None (1) · Plasma ~5 hours; biologic ~36-54 hours'"`UNIQ--ref-0000101A-QINU`"' (1)
bioavailability:
None (1) · Oral ~70%; depot IM provides sustained release over weeks'"`UNIQ--ref-0000101B-QINU`"' (1)
pregnancy:
None (2)
legal:
None (1) · [[USLegal:Prescription only|Rx-only]] in US (1)

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