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Drilldown: Medicines

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Medicines > generic : 2-AI or Memantine ER / Donepezil

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generic: (Click arrow to add another value)
brand:
None (1) · Namzaric (1)
classes:
Combined cholinesterase inhibitor + NMDA antagonist (1) · Research material (1) · Stimulant (1)
mechanism:
Alpha-methylated amphetamine analogue; norepinephrine releasing agent (1) · Donepezil: reversible AChE inhibitor, increases synaptic acetylcholine. Memantine: uncompetitive low-affinity NMDA receptor antagonist, dampens pathological glutamate overactivation while preserving normal synaptic signaling. Targets two distinct mechanisms in Alzheimer's. (1)
uses:
None (1) · '"`UNIQ--vote-00000468-QINU`"' (1)
starting dose:
None (1) · For patients already stable on memantine 28 mg/d + donepezil 10 mg/d, switch to one capsule daily of equivalent strength (1)
preparations:
None (1) · 7/10, 14/10, 21/10, 28/10 mg ER capsules (memantine ER / donepezil) (1)
fda max:
None (1) · 28/10 mg/d (1)
routes:
None (1) · Oral (capsule whole or opened/sprinkled on applesauce) (1)
onset:
None (1) · Component effects accumulate over weeks (1)
duration:
None (1) · 24 h (1)
halflife:
None (1) · ~60–80 h (memantine); ~70 h (donepezil) (1)
bioavailability:
None (1) · ~100% both components (1)
pregnancy:
None (1) · Not relevant (geriatric problem) (1)
legal:
None (1) · Rx-only in US (1)

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