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Medicines > generic : 2-AI or Norethindrone (norethisterone outside US)

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generic: (Click arrow to add another value)
brand:
None (1) · Aygestin (5 mg, Rx); Camila, Errin, Heather, Jolivette, Nor-QD, Ortho Micronor, Sharobel (0.35 mg POPs); component of many COCs (1)
classes:
Research material (1) · Stimulant (1) · [[:Category:Hormonal_contraceptives|Hormonal contraceptive]] (1) · [[:Category:Progestins|Progestin (synthetic progestogen)]] (1) · [[:Category:Sex_hormones|Sex hormone]] (1)
mechanism:
Alpha-methylated amphetamine analogue; norepinephrine releasing agent (1) · '"`UNIQ--vote-000013EE-QINU`"' Higher-dose Aygestin (5 mg) achieves more reliable ovulation suppression and is used for endometriosis and DUB. POP requires strict daily timing because the 24-hour cervical-mucus effect window is narrower than COC'"`UNIQ--ref-000013EF-QINU`"'. (1)
uses:
None (1) · '"`UNIQ--vote-000013F0-QINU`"', '"`UNIQ--vote-000013F1-QINU`"', '"`UNIQ--vote-000013F2-QINU`"', '"`UNIQ--vote-000013F3-QINU`"', '"`UNIQ--vote-000013F4-QINU`"' (1)
starting dose:
None (1) · POP: 0.35 mg PO daily continuously (no placebo week); high-dose 5 mg Aygestin for amenorrhea/endometriosis 5-10 mg/d (1)
preparations:
None (1) · 0.35 mg POP tablets; 5 mg tablets (Aygestin); component of COCs and combination HRT (1)
fda max:
None (1) · Indication-specific (1)
routes:
None (1) · Oral (1)
onset:
None (1) · Contraception within 48 hours of starting (POP); endometrial effects days (1)
duration:
None (1) · ~24 hours per dose (strict timing required for POP — within 3-hour window each day) (1)
halflife:
None (1) · ~8 hours'"`UNIQ--ref-000013F5-QINU`"' (1)
bioavailability:
None (1) · ~65% (oral)'"`UNIQ--ref-000013F6-QINU`"' (1)
pregnancy:
None (1) · Contraindicated in known pregnancy (Aygestin); the 0.35 mg POP is not teratogenic and does not need to be discontinued before conception planning.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
None (1) · [[USLegal:Prescription only|Rx-only]] in US (note: norgestrel 0.075 mg POP is now OTC as Opill since 2023, but norethindrone POP remains Rx) (1)

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