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Medicines > generic : 2-AI or Prednisolone (and prednisolone sodium phosphate, acetate, etc.)

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generic: (Click arrow to add another value)
brand:
None (1) · Prelone, Pediapred, Orapred ODT, Millipred, Veripred (1)
classes:
Research material (1) · Stimulant (1) · [[:Category:Corticosteroids|Corticosteroid]] (1) · [[:Category:Glucocorticoids|Glucocorticoid (intermediate-acting)]] (1) · [[:Category:Immunosuppressants|Immunosuppressant]] (1)
mechanism:
Alpha-methylated amphetamine analogue; norepinephrine releasing agent (1) · '"`UNIQ--vote-000008BE-QINU`"' Preferred over prednisone in advanced hepatic dysfunction where hepatic 11β-HSD1 activation is impaired. Liquid formulations are the workhorse pediatric oral corticosteroid for asthma and croup'"`UNIQ--ref-000008BF-QINU`"'. (1)
uses:
None (1) · '"`UNIQ--vote-000008C0-QINU`"', '"`UNIQ--vote-000008C1-QINU`"', '"`UNIQ--vote-000008C2-QINU`"', '"`UNIQ--vote-000008C3-QINU`"' (1)
starting dose:
None (1) · Pediatric 1-2 mg/kg/d (max 60 mg) PO for asthma exacerbation; adult dosing similar to prednisone milligram-for-milligram (~1:1 potency) (1)
preparations:
None (1) · 5 mg tablets; 5 mg/5 mL, 10 mg/5 mL, 15 mg/5 mL oral solutions (sweetened pediatric); 5 mg/5 mL syrup; ophthalmic 0.12%, 1% suspensions and 1% solution (1)
fda max:
None (1) · Indication-specific (1)
routes:
None (1) · IM (1) · IV (prednisolone sodium phosphate) (1) · ophthalmic (1) · Oral (1)
onset:
None (1) · Hours (1)
duration:
None (1) · Biologic 12-36 hours (intermediate-acting) (1)
halflife:
None (1) · Plasma 2-3 hours; biologic ~18-36 hours'"`UNIQ--ref-000008C4-QINU`"' (1)
bioavailability:
None (1) · ~70% (oral)'"`UNIQ--ref-000008C5-QINU`"' (1)
pregnancy:
None (1) · Use when benefits outweigh; small association with oral clefts debated.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
None (1) · [[USLegal:Prescription only|Rx-only]] in US (1)

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