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Medicines > generic : 2-FA or 25I-NBOMe or Losartan

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generic: (Click arrow to add another value)
brand:
None (2) · Cozaar (1)
classes:
Amphetamine (1) · Classic Psychedelic (1) · Phenethylamine (1) · Research material (2) · Stimulant (1) · [[:Category:Angiotensin_receptor_blockers|Angiotensin receptor blocker (ARB)]] (1) · [[:Category:Antihypertensives|Antihypertensive]] (1)
mechanism:
Extremely potent 5-HT2A agonist; vasoconstrictor (1) · Monoamine releasing agent (1) · '"`UNIQ--vote-000000B6-QINU`"' Active metabolite EXP3174 is ~10-40-fold more potent than the parent and accounts for most of the antihypertensive effect; CYP2C9 polymorphism affects conversion'"`UNIQ--ref-000000B7-QINU`"'. (1)
uses:
None (2) · '"`UNIQ--vote-000000B8-QINU`"', '"`UNIQ--vote-000000B9-QINU`"', '"`UNIQ--vote-000000BA-QINU`"', '"`UNIQ--vote-000000BB-QINU`"' (1)
starting dose:
None (2) · 50 mg PO daily (25 mg in volume depletion or hepatic impairment) (1)
preparations:
None (2) · 25 mg, 50 mg, 100 mg tablets (1)
fda max:
None (2) · 100 mg/d (1)
routes:
None (2) · Oral (1)
onset:
None (2) · BP effect 1-2 weeks; antihypertensive peak 3-6 weeks (1)
duration:
None (2) · 24 hours (1)
halflife:
None (2) · 2 hours (parent); 6-9 hours for active carboxylic acid metabolite EXP3174'"`UNIQ--ref-000000BC-QINU`"' (1)
bioavailability:
None (2) · ~33% (extensive first-pass via CYP2C9 and CYP3A4)'"`UNIQ--ref-000000BD-QINU`"' (1)
pregnancy:
None (2) · '''Contraindicated in pregnancy''' (all trimesters); fetal renal injury, oligohydramnios, hypocalvaria, hypotension. Stop on detection'"`UNIQ--ref-000000BE-QINU`"' (1)
legal:
None (2) · [[USLegal:Prescription only|Rx-only]] in US (1)

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