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Medicines > generic : 2-FA or Bupropion / Naltrexone

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generic: (Click arrow to add another value)
brand:
None (1) · Contrave (US), Mysimba (EU) (1)
classes:
Amphetamine (1) · atypical)]] (1) · Research material (1) · Stimulant (1) · [[:Category:Anorectics|Anorectic (weight-loss agent)]] (1) · [[:Category:Antidepressants|Antidepressant (bupropion (1) · [[:Category:Fixed-dose_combinations|Fixed-dose combination]] (1) · [[:Category:Opioid_antagonists|Opioid antagonist (naltrexone)]] (1)
mechanism:
None (1) · Monoamine releasing agent (1)
uses:
None (1) · '"`UNIQ--vote-00001567-QINU`"' (1)
starting dose:
None (1) · Week 1: 1 tablet (8/90 mg) PO morning; week 2: 1 tablet AM + 1 PM; week 3: 2 AM + 1 PM; week 4 onward: 2 AM + 2 PM (32 mg naltrexone / 360 mg bupropion/d) (1)
preparations:
None (1) · 8 mg naltrexone / 90 mg bupropion ER tablets (titration-pack design) (1)
fda max:
None (1) · 32 mg naltrexone / 360 mg bupropion per day (1)
routes:
None (1) · Oral (1)
onset:
None (1) · Modest appetite suppression within weeks; weight loss over months (1)
duration:
None (1) · 12 hours (BID dosing required) (1)
halflife:
None (1) · Naltrexone ~4 hours (6β-naltrexol metabolite ~13 hours); bupropion ~21 hours'"`UNIQ--ref-00001568-QINU`"' (1)
bioavailability:
None (1) · Naltrexone ~5% (oral, extensive first-pass to 6β-naltrexol); bupropion ER ~87%'"`UNIQ--ref-00001569-QINU`"' (1)
pregnancy:
None (1) · Contraindicated in pregnancy (FDA label).<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
None (2)

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