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Medicines > generic : 2-FDCK or 2C-B or Venlafaxine

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generic: (Click arrow to add another value)
brand:
None (1) · Effexor XR, Effexor IR (discontinued in US, generic widely available) (1) · Nexus, Eroxan (historical, late-1980s through mid-1990s) (1)
classes:
2C-x series (1) · Dissociative (1) · Phenethylamine (1) · Psychedelic (1) · Research material (1) · [[:Category:Antidepressants|Antidepressant]] (1) · [[:Category:Anxiolytics|Anxiolytic]] (1) · [[:Category:SNRIs|Serotonin-norepinephrine reuptake inhibitor (SNRI)]] (1)
mechanism:
None (1) · 5-HT2A partial agonist (1) · NMDA antagonist; fluorinated ketamine analogue (1)
uses:
None (2) · '"`UNIQ--vote-0000001F-QINU`"', '"`UNIQ--vote-00000020-QINU`"', '"`UNIQ--vote-00000021-QINU`"', '"`UNIQ--vote-00000022-QINU`"', '"`UNIQ--vote-00000023-QINU`"', '"`UNIQ--vote-00000024-QINU`"', '"`UNIQ--vote-00000025-QINU`"' (1)
starting dose:
None (2) · XR 37.5 mg PO once daily for 4-7 days, then 75 mg/day; titrate by 75 mg every ≥4 days to clinical effect. IR 25-37.5 mg BID-TID (1)
preparations:
None (2) · IR tablets 25, 37.5, 50, 75, 100 mg; XR capsules 37.5, 75, 150, 225 mg (1)
fda max:
None (2) · 225 mg/day outpatient (XR); 375 mg/day inpatient (IR divided TID); 75 mg/day in moderate hepatic impairment (1)
routes:
None (1) · insufflated (1) · Oral (2) · PR (1)
onset:
None (1) · 45-75 min (oral) (1) · Antidepressant effect over 1-2 weeks; anxiolytic effect over 4-6 weeks (1)
duration:
None (1) · 24 hours (XR); 12 hours (IR) (1) · 4-8 h (1)
halflife:
None (1) · Not well characterized (1) · Venlafaxine 5 hours; desvenlafaxine active metabolite 11 hours'"`UNIQ--ref-00000026-QINU`"' (1)
bioavailability:
None (1) · Not well characterized (1) · ~45%'"`UNIQ--ref-00000027-QINU`"' (1)
pregnancy:
None (1) · Not established (1) · Observational signal for neonatal adaptation syndrome with late-pregnancy exposure; weigh against the risks of untreated maternal depression.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
None (1) · [[USLegal:DEA Schedule I|Schedule I]] (United States) (1) · [[USLegal:Prescription only|Rx-only]] in US. Carries the antidepressant '''Boxed Warning''' for suicidality in children, adolescents, and young adults'"`UNIQ--ref-00000028-QINU`"' (1)

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