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Medicines > generic : 2-FDCK or Codeine or Liothyronine (T3, triiodothyronine sodium)

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generic: (Click arrow to add another value)
brand:
None (2) · (multiple, generic dominant) (1) · Cytomel (oral), Triostat (IV) (1)
classes:
Analgesic (2) · Dissociative (1) · Opioid (2) · Prodrug (1) · Research material (1) · [[:Category:Hormone_replacement|Hormone replacement]] (1) · [[:Category:Thyroid_hormones|Thyroid hormone]] (1)
mechanism:
None (1) · Mu-opioid receptor agonist; prodrug (metabolized to morphine) (1) · NMDA antagonist; fluorinated ketamine analogue (1) · Prodrug; converted to [[Morphine|morphine]] by [[Enzyme:CYP2D6|CYP2D6]] for analgesic action. (1)
uses:
None (2) · Mild to moderate pain; cough suppression (low-dose). (1) · '"`UNIQ--vote-0000149A-QINU`"', '"`UNIQ--vote-0000149B-QINU`"', '"`UNIQ--vote-0000149C-QINU`"' (1)
starting dose:
None (2) · Adult: 15–60 mg every 4 hours as needed. (1) · Hypothyroidism: 5-25 mcg PO daily (start low, titrate slowly); myxedema coma: 5-20 mcg IV q4-12h with T4 loading (1)
preparations:
None (2) · 5, 25, 50 mcg tablets (Cytomel); 10 mcg/mL IV (Triostat) (1) · Tablet (15, 30, 60 mg); oral solution; combination products (with [[Acetaminophen|acetaminophen]] or ibuprofen). (1)
fda max:
None (2) · 100 mcg/d typical (1) · 360 mg/day (1)
routes:
None (2) · IV (1) · Oral (1) · PO (only formulation marketed in the US). (1)
onset:
None (2) · 30–60 min (PO) (1) · Hours (faster than T4); peak biologic activity 24-48 hours (1)
duration:
None (2) · 24-72 hours (1) · 4–6 hours (1)
halflife:
None (2) · 2.5–3 hours (1) · ~1 day (much shorter than T4's ~7 days)'"`UNIQ--ref-0000149D-QINU`"' (1)
bioavailability:
None (2) · ~50% (variable, CYP2D6-dependent for analgesic effect). (1) · ~95% (oral)'"`UNIQ--ref-0000149E-QINU`"' (1)
pregnancy:
None (2) · Avoid; risk of neonatal opioid withdrawal with chronic use; UM-mother breastfeeding contraindicated. (1) · T4 (levothyroxine) is the first-line in pregnancy; T3 is rarely needed.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
None (2) · US Schedule II (single-entity); Schedule III–V (combination products by content). (1) · [[USLegal:Prescription only|Rx-only]] in US (1)

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