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Drilldown: Medicines

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Medicines > generic : 2-FMA or 2C-B or Lactulose

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generic: (Click arrow to add another value)
brand:
None (1) · Kristalose, Constulose, Generlac, Enulose (1) · Nexus, Eroxan (historical, late-1980s through mid-1990s) (1)
classes:
2C-x series (1) · Amphetamine (1) · Phenethylamine (1) · Psychedelic (1) · Research material (1) · Stimulant (1) · [[:Category:Disaccharides|Non-absorbable disaccharide]] (1) · [[:Category:Hepatic_encephalopathy_treatments|Hepatic encephalopathy treatment]] (1) · [[:Category:Osmotic_laxatives|Osmotic laxative]] (1)
mechanism:
None (1) · 5-HT2A partial agonist (1) · Monoamine releasing agent (1)
uses:
None (2) · '"`UNIQ--vote-00000F5C-QINU`"', '"`UNIQ--vote-00000F5D-QINU`"' (1)
starting dose:
None (2) · Constipation: 15-30 mL PO daily (titrate to 1-2 soft stools/day); hepatic encephalopathy: 20-30 g (30-45 mL) PO/PR every 1-2 hours acutely until soft stools, then BID-QID to target 2-3 soft stools/day (1)
preparations:
None (2) · 10 g/15 mL solution (Constulose); 10 g, 20 g powder packets (Kristalose) (1)
fda max:
None (2) · Indication-specific; HE may require high-volume dosing (1)
routes:
None (1) · especially in acute HE) (1) · insufflated (1) · Oral (2) · PR (1) · rectal (enema (1)
onset:
None (1) · 45-75 min (oral) (1) · Constipation: 24-48 hours; HE: ammonia reduction within hours of stool production (1)
duration:
None (1) · 4-8 h (1) · Hours (1)
halflife:
None (1) · Not meaningfully described — lactulose is not significantly absorbed (1) · Not well characterized (1)
bioavailability:
None (1) · <3% systemic absorption (the basis of the safety and mechanism)'"`UNIQ--ref-00000F5E-QINU`"' (1) · Not well characterized (1)
pregnancy:
None (1) · Generally considered safe (minimal systemic absorption).<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1) · Not established (1)
legal:
None (1) · [[USLegal:DEA Schedule I|Schedule I]] (United States) (1) · [[USLegal:Prescription only|Rx-only]] in US (1)

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