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Medicines > generic : 2-FMA or Codeine or Guaifenesin

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generic: (Click arrow to add another value)
brand:
None (2) · (multiple, generic dominant) (1) · Mucinex, Robitussin, Tussin (1)
classes:
Amphetamine (1) · Analgesic (2) · Opioid (2) · Prodrug (1) · Research material (1) · Stimulant (1) · [[:Category:Expectorants|Expectorant]] (1) · [[:Category:Mucolytics|Mucolytic]] (1)
mechanism:
Monoamine releasing agent (1) · Mu-opioid receptor agonist; prodrug (metabolized to morphine) (1) · Prodrug; converted to [[Morphine|morphine]] by [[Enzyme:CYP2D6|CYP2D6]] for analgesic action. (1) · '"`UNIQ--vote-0000104D-QINU`"' Adequate hydration is at least as important as the drug in producing the expectorant effect clinically. Used in combination with dextromethorphan, decongestants, or antihistamines in many proprietary OTC cold preparations. (1)
uses:
None (2) · Mild to moderate pain; cough suppression (low-dose). (1) · '"`UNIQ--vote-0000104E-QINU`"', '"`UNIQ--vote-0000104F-QINU`"' (1)
starting dose:
None (2) · 200-400 mg PO q4h (IR); 600-1200 mg PO q12h (Mucinex 12-Hour ER) (1) · Adult: 15–60 mg every 4 hours as needed. (1)
preparations:
None (2) · 100, 200, 400 mg IR tablets; 600 mg, 1200 mg Mucinex ER tablets; many liquid formulations and combination products with dextromethorphan, pseudoephedrine, antihistamines (1) · Tablet (15, 30, 60 mg); oral solution; combination products (with [[Acetaminophen|acetaminophen]] or ibuprofen). (1)
fda max:
None (2) · 2.4 g/d (1) · 360 mg/day (1)
routes:
None (2) · Oral (1) · PO (only formulation marketed in the US). (1)
onset:
None (2) · 30 minutes (1) · 30–60 min (PO) (1)
duration:
None (2) · 4 hours (IR); 12 hours (ER) (1) · 4–6 hours (1)
halflife:
None (2) · 2.5–3 hours (1) · ~1 hour'"`UNIQ--ref-00001050-QINU`"' (1)
bioavailability:
None (2) · High (oral)'"`UNIQ--ref-00001051-QINU`"' (1) · ~50% (variable, CYP2D6-dependent for analgesic effect). (1)
pregnancy:
None (2) · Avoid; risk of neonatal opioid withdrawal with chronic use; UM-mother breastfeeding contraindicated. (1) · Generally considered acceptable.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
None (2) · OTC in US (1) · US Schedule II (single-entity); Schedule III–V (combination products by content). (1)

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