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Medicines > generic : 25B-NBOMe or Codeine or Fexofenadine

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generic: (Click arrow to add another value)
brand:
None (2) · (multiple, generic dominant) (1) · Allegra, Allegra Allergy 24 Hour, Mucinex Allergy (combo) — all now OTC in US (1)
classes:
Analgesic (2) · Classic Psychedelic (1) · Opioid (2) · Phenethylamine (1) · Prodrug (1) · Research material (1) · [[:Category:Antihistamines|Antihistamine]] (1) · [[:Category:H1_receptor_antagonists|Histamine H1 receptor antagonist (second-generation)]] (1)
mechanism:
Mu-opioid receptor agonist; prodrug (metabolized to morphine) (1) · Potent 5-HT2A agonist; no oral activity (1) · Prodrug; converted to [[Morphine|morphine]] by [[Enzyme:CYP2D6|CYP2D6]] for analgesic action. (1) · '"`UNIQ--vote-00000CC9-QINU`"' Mostly excreted unchanged in feces and urine; P-glycoprotein substrate (the basis of the fruit-juice interaction). (1)
uses:
None (2) · Mild to moderate pain; cough suppression (low-dose). (1) · '"`UNIQ--vote-00000CCA-QINU`"', '"`UNIQ--vote-00000CCB-QINU`"' (1)
starting dose:
None (2) · 60 mg PO BID or 180 mg PO once daily (1) · Adult: 15–60 mg every 4 hours as needed. (1)
preparations:
None (2) · 30, 60, 180 mg tablets; 30 mg ODT; 6 mg/mL oral suspension; all OTC (1) · Tablet (15, 30, 60 mg); oral solution; combination products (with [[Acetaminophen|acetaminophen]] or ibuprofen). (1)
fda max:
None (2) · 180 mg/d (adults) (1) · 360 mg/day (1)
routes:
None (2) · Oral (1) · PO (only formulation marketed in the US). (1)
onset:
None (2) · 1-2 hours (1) · 30–60 min (PO) (1)
duration:
None (2) · 12-24 hours (1) · 4–6 hours (1)
halflife:
None (2) · 2.5–3 hours (1) · ~14 hours'"`UNIQ--ref-00000CCC-QINU`"' (1)
bioavailability:
None (2) · ~33% (oral; fruit juices including grapefruit, orange, and apple reduce absorption substantially via OATP1A2 inhibition — distinctive interaction not seen with most other H1s)'"`UNIQ--ref-00000CCD-QINU`"' (1) · ~50% (variable, CYP2D6-dependent for analgesic effect). (1)
pregnancy:
None (2) · Avoid; risk of neonatal opioid withdrawal with chronic use; UM-mother breastfeeding contraindicated. (1) · Generally considered safe; loratadine and cetirizine have more pregnancy data and are typically preferred.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
None (2) · OTC in US (1) · US Schedule II (single-entity); Schedule III–V (combination products by content). (1)

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